Sant Pau - Institut de Recerca

Main lines of research

Atherosclerosis mechanisms

Analysis of apolipoprotein J (apoJ) as a marker of CVR.
Use of mimetic peptides derived from apoJ as therapeutic tools.
Involvement of LDL(-) on lipid accumulation in cardiomyocytes and heart failure.

Inflammatory mechanisms induced by LDL(-) on monocytes from patients with diabetes.

Diagnosis of chronic or acute cardiovascular diseases.
Development of algorithms for ruling-out acute coronary disease.
Assessment of new biomarkers of acute cardiovascular disease: cardiac troponins, natriuretic peptides, ST-2.
Development of methods for point-ofcare biomarker measurement.
Vulnerability markers in atheromatous plaque: electronegative LDL, LDL size, HDL function, myeloperoxidase, phospholipase.

Challenges

Determine the intracellular mechanisms involved in the inflammatory response induced by LDL(-) and the components of the particle that entail atherogenicity.
Analyse the therapeutic potential of mimetic peptides derived from apo J to delay the development of atherosclerosis in animal models.
Demonstrate that electronegative LDL is a marker of vulnerable atheromatous plaque.
Find new markers of cardiovascular risk in diseases such as diabetes, HIV or cardiac failure.

Coordinació del grup

SANCHEZ QUESADA, JOSE LUIS IR
jsanchezq@santpau.cat

Membres

Benitez Gonzalez, Sonia IR
Freixa Martin, Julia FGS
Garcia Osuna, Alvaro FGS
Grau Agramunt, Margarita FGS
Porcel Jabalera, Inmaculada FGS
Puig Grifol, Nuria IR
Rives Jimenez, Jose FGS

Publicacions 2021

Aengevaeren VL, van RRJ, Ordonez J, Garcia A, Kaier TE, Marber M, Froeling M, van den Berg S, Hooijmans MT, Monte JR, Hopman M, Strijkers GJ, Nederveen AJ, Bakermans AJ, Eijsvogels TMH. Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing. Journal of the American Heart Association. 2021; 10(13):e020039. DOI:10.1161/JAHA.120.020039. PMID:34180243. IF:6,106.
Alvarez J, Garcia A, Vives M, Ferrero A, Martinez M, Vazquez R, Gonzalez JR, Rivera M, Segovia J, Pascual D, Bover R, Bascompte R, Delgado J, Sepulveda AG, Bardaji A, Perez F, Zamorano JL, Crespo M, Sanchez PL, Ordonez J, Cinca J. A 3-Biomarker 2-Point-Based Risk Stratification Strategy in Acute Heart Failure. Frontiers in Physiology. 2021; 12:708890. DOI:10.3389/fphys.2021.708890. PMID:34744758. IF:4,755.
Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
Camps P, Jimenez E, Soler M, Puig N, Aguilera A, Marin R, Prats L, Delgado R, Martinez A, Guisado D, Guasch M, Marti J. Endothelial Progenitor Cells Count after Acute Ischemic Stroke Predicts Functional Outcome in Patients with Carotid Atherosclerosis. Journal of Stroke & Cerebrovascular Diseases. 2021; 30(12):106144. DOI:10.1016/j.jstrokecerebrovasdis.2021.106144. PMID:34649037. IF:2,677.
Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
Chen DY, Sawamura T, Dixon R, Sanchez JL, Chen CH. Autoimmune Rheumatic Diseases: An Update on the Role of Atherogenic Electronegative LDL and Potential Therapeutic Strategies. Journal of Clinical Medicine. 2021; 10(9):1992. DOI:10.3390/jcm10091992. PMID:34066436. IF:4,964.
Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
Crovetto F, Crispi F, Llurba E, Pascal R, Larroya M, Trilla C, Camacho M, Medina C, Dobano C, Gomez MD, Figueras F, Gratacos E, Garcia A, Mora J. Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnancy Outcomes: A Population-based Study. CLINICAL INFECTIOUS DISEASES. 2021; 73(10). DOI:10.1093/cid/ciab104. PMID:33556958. IF:20,999.
Diaz SO, Sanchez JL, de Freitas V, Leite A, Barros AS, Reis A. Exploratory analysis of large-scale lipidome in large cohorts: are we any closer of finding lipid-based markers suitable for CVD risk stratification and management?. ANALYTICA CHIMICA ACTA. 2021; 11D42OI:10.1016/j.aca.2020.10.037. PMID:33280696. IF:6,911.
Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Minambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021; 31(2):517-522. DOI: 10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Saumoy M, Di S, Perez S, Sanchez JL, Valdivielso JM, Subirana I, Imaz A, Tiraboschi JM, Garcia B, Ordonez J, Benitez S, Podzamczer D, Grau M. Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations. HIV MEDICINE. 2021; 22(7). DOI:10.1111/hiv.13093. PMID:33817938. IF:3,094.
Saumoy M, Sanchez JL, Ordonez J, Podzamczer D. Do All Integrase Strand Transfer Inhibitors Have the Same Lipid Profile? Review of Randomised Controlled Trials in Naive and Switch Scenarios in HIV-Infected Patients. Journal of Clinical Medicine. 2021; 10(16):3456. DOI:10.3390/jcm10163456. PMID:34441755. IF:4,964.
Ullmo J, Cruz M, Sanchez O, Bos L, De la Llama PF, Calero F, Dominguez C, Garrido C, Trilla C, Carreras F, Sionis A, Mora J, Garcia A, Ordonez J, Llurba E. Cardiac dysfunction and remodeling regulated by anti-angiogenic environment in patients with preeclampsia: the ANGIOCOR prospective cohort study protocol. BMC Pregnancy and Childbirth. 2021; 21(1):816. DOI:10.1186/s12884-021-04263-w. PMID:34879854. IF:3,105.

Álvarez-García J, Valero MJ, Solé-González E, Andreu Ferrero-Gregoria, Miquel Vives-Borrás, Rafael Vázquez-García, José Ramón González-Juanatey, Pablo García-Pavía, Domingo Pascual Figal, Ramón Bover, Ramón Bascompte, Juan Delgado, Alfredo Bardají, Félix Pérez-Villa, José Luis Zamorano, María G.Crespo-Leiro, Pedro Luis Sánchez, Álvaro García-Osuna, Luis Alberto Robledo-Escobar, Antonio Bayés de Luna, Manuel Martínez-Sellés, Juan Cinca, on behalf of investigators of the Spanish Heart Failure Network (REDINSCOR II). Prevalence, clinical profile and prognostic implications of interatrial block in patients admitted for heart failure. REC CARDIOCLINICS. 2020;55(3):155-164. DOI:10.1016/j.rccl.2020.03.011. IF: 4,642

Apple FS, Collinson PO, Kavsak PA, Body R, Ordóñez-Llanos J, Saenger AK, Omland T, Hammarsten O, Jaffe AS; IFCC Committee Clinical Application of Cardiac Biomarkers. The IFCC Clinical Application of Cardiac Biomarkers Committee’s Appraisal of the 2020 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation: Getting Cardiac Troponin Right. CLIN CHEM. 2020 Dec 30:hvaa337. doi: 10.1093/clinchem/hvaa337. Epub ahead of print. PMID: 33377906. IF: 8,327

Cedo L., Metso J., Santos D., Garcia-Leon A., Plana N., Sabate-Soler S., Rotllan N., Rivas-Urbina A., Mendez-Lara K.A., Tondo M., Girona J., Julve J., Pallares V., Benitez-Amaro A., Llorente-Cortes V., Perez A., Gomez-Coronado D., Ruotsalainen A.-K., Levonen A.-L., Sanchez-Quesada J.L., Masana L., Kovanen P.T., Jauhiainen M., Lee-Rueckert M., Blanco-Vaca F., Escola-Gil J.C. (2020) LDL receptor regulates the reverse transport of macrophage-derived unesterified cholesterol via concerted action of the HDL-LDL Axis: Insight from mouse models. CIRC RES, 127 (6), 778-792. IF: 17,3670

De Gonzalo-Calvo D, Barroeta I, Nan MN, Rives J, Garzón D, Carmona-Iragui M, Benejam B, Videla L, Fernández S, Altuna M, Valldeneu S, Blesa R, Lleó A, Blanco-Vaca F, Fortea J, Tondo M. Evaluation of biochemical and hematological parameters in adults with Down syndrome. SCI REP. 2020 Aug 13;10(1):13755. doi: 10.1038/s41598-020-70719-2. PMID: 32792619; PMCID: PMC7426851. IF: 4,379

Di Yacovo S., Saumoy M., Sanchez-Quesada J.L., Navarro A., Sviridov D., Javaloyas M., Vila R., Vernet A., Low H., Penafiel J., Garcia B., Ordonez-Llanos J., Podzamczer D. (2020) Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study. PLOS ONE, 15 (8 August), e0237739-. IF: 3,2400

Genua I., Ramos A., Caimari F., Balague C., Sanchez-Quesada J.L., Perez A., Minambres I. (2020) Effects of Bariatric Surgery on HDL Cholesterol. OBES SURG, 30 (5), 1793-1798. IF: 4,1290

Jayaraman S., Chavez O.R., Perez A., Minambres I., Sanchez-Quesada J.L., Gursky O. (2020) Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia. BBA-MOL CELL BIOL L, 1865 (8), -. IF: 4,6980

Mendez Fernandez AB, Ferrero-Gregori A, Garcia-Osuna A, Mirabet-Perez S, Pirla-Buxo MJ, Cinca-Cuscullola J, Ordonez-Llanos J, Roig Minguell E. Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction. ESC HEART FAIL. 2020 Oct;7(5):2223-2229. doi: 10.1002/ehf2.12621. Epub 2020 Jun 26. PMID: 32589369; PMCID: PMC7524215. IF: 4,411

Permanyer E., Munoz-Guijosa C., Padro J.-M., Ginel A., Montiel J., Sanchez-Quesada J.L., Vila L., Camacho M. (2020) Mini-extracorporeal circulation surgery produces less inflammation than off-pump coronary surgery. EUR J CARDIO-THORAC, 57 (3), 496-503. IF: 4,1910

Puig N, Jiménez-Xarrié E, Camps-Renom P, Benitez S. Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability. INT J MOL SCI. 2020 Nov 3;21(21):8236. doi: 10.3390/ijms21218236. PMID: 33153204; PMCID:PMC7662861. IF: 5,923

Puig N, Miñambres I, Benítez S, Gil P, Grau-Agramunt M, Rivas-Urbina A, Pérez A, Sánchez-Quesada JL. Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia. BIOMEDICINES. 2020 Jan 6;8(1):6. doi: 10.3390/biomedicines8010006. PMID: 31935793; PMCID: PMC7168323. IF: 6,081

Puig N, Montolio L, Camps-Renom P, Navarra L, Jiménez-Altayó F, Jiménez-Xarrié E, Sánchez-Quesada JL, Benitez S. Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages. CELLS. 2020 Mar 1;9(3):583. doi: 10.3390/cells9030583. PMID: 32121518; PMCID: PMC7140452. IF: 6,600

Rivas-Urbina A, Rull A, Aldana-Ramos J, Santos D, Puig N, Farre-Cabrerizo N, Benitez S, Perez A, de Gonzalo-Calvo D, Escola-Gil JC, Julve J, Ordoñez-Llanos J, Sanchez-Quesada JL. Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113-122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice. BIOMOLECULES. 2020 May 29;10(6):829. doi: 10.3390/biom10060829. PMID: 32485898; PMCID: PMC7356811. IF: 4,879

Rivas-Urbina A., Rull A., Montoliu-Gaya L., Perez-Cuellar M., Ordonez-Llanos J., Villegas S., Sanchez-Quesada J.L. (2020) Low-density lipoprotein aggregation is inhibited by apolipoprotein J-derived mimetic peptide D-[113–122]apoJ. BBA-MOL CELL BIOL L, 1865 (2), -. IF: 4,6980

2017 Scientific Report – Cardiovascular Biochemistry

presentació

Main lines of research

Atherosclerosis mechanisms

Analysis of apolipoprotein J (apoJ) as a marker of CVR.
Use of mimetic peptides derived from apoJ as therapeutic tools.
Involvement of LDL(-) on lipid accumulation in cardiomyocytes and heart failure.

Inflammatory mechanisms induced by LDL(-) on monocytes from patients with diabetes.

Diagnosis of chronic or acute cardiovascular diseases.
Development of algorithms for ruling-out acute coronary disease.
Assessment of new biomarkers of acute cardiovascular disease: cardiac troponins, natriuretic peptides, ST-2.
Development of methods for point-ofcare biomarker measurement.
Vulnerability markers in atheromatous plaque: electronegative LDL, LDL size, HDL function, myeloperoxidase, phospholipase.

Challenges

Determine the intracellular mechanisms involved in the inflammatory response induced by LDL(-) and the components of the particle that entail atherogenicity.
Analyse the therapeutic potential of mimetic peptides derived from apo J to delay the development of atherosclerosis in animal models.
Demonstrate that electronegative LDL is a marker of vulnerable atheromatous plaque.
Find new markers of cardiovascular risk in diseases such as diabetes, HIV or cardiac failure.

equip

Coordinació del grup

SANCHEZ QUESADA, JOSE LUIS IR
jsanchezq@santpau.cat

Membres

Benitez Gonzalez, Sonia IR
Freixa Martin, Julia FGS
Garcia Osuna, Alvaro FGS
Grau Agramunt, Margarita FGS
Porcel Jabalera, Inmaculada FGS
Puig Grifol, Nuria IR
Rives Jimenez, Jose FGS

producció científica

Publicacions 2021

Aengevaeren VL, van RRJ, Ordonez J, Garcia A, Kaier TE, Marber M, Froeling M, van den Berg S, Hooijmans MT, Monte JR, Hopman M, Strijkers GJ, Nederveen AJ, Bakermans AJ, Eijsvogels TMH. Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing. Journal of the American Heart Association. 2021; 10(13):e020039. DOI:10.1161/JAHA.120.020039. PMID:34180243. IF:6,106.
Alvarez J, Garcia A, Vives M, Ferrero A, Martinez M, Vazquez R, Gonzalez JR, Rivera M, Segovia J, Pascual D, Bover R, Bascompte R, Delgado J, Sepulveda AG, Bardaji A, Perez F, Zamorano JL, Crespo M, Sanchez PL, Ordonez J, Cinca J. A 3-Biomarker 2-Point-Based Risk Stratification Strategy in Acute Heart Failure. Frontiers in Physiology. 2021; 12:708890. DOI:10.3389/fphys.2021.708890. PMID:34744758. IF:4,755.
Amaro AB, Curco AS, Garcia E, Julve J, Rives J, Benitez S, Cortes VL. Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of Clinical Medicine. 2021; 10(16):3571. DOI:10.3390/jcm10163571. PMID:34441867. IF:4,964.
Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF:4,757.
Camps P, Jimenez E, Soler M, Puig N, Aguilera A, Marin R, Prats L, Delgado R, Martinez A, Guisado D, Guasch M, Marti J. Endothelial Progenitor Cells Count after Acute Ischemic Stroke Predicts Functional Outcome in Patients with Carotid Atherosclerosis. Journal of Stroke & Cerebrovascular Diseases. 2021; 30(12):106144. DOI:10.1016/j.jstrokecerebrovasdis.2021.106144. PMID:34649037. IF:2,677.
Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF:4,757.
Chen DY, Sawamura T, Dixon R, Sanchez JL, Chen CH. Autoimmune Rheumatic Diseases: An Update on the Role of Atherogenic Electronegative LDL and Potential Therapeutic Strategies. Journal of Clinical Medicine. 2021; 10(9):1992. DOI:10.3390/jcm10091992. PMID:34066436. IF:4,964.
Colom C, Rull A, Sanchez JL, Perez A. Cardiovascular Disease in Type 1 Diabetes Mellitus: Epidemiology and Management of Cardiovascular Risk. Journal of Clinical Medicine. 2021; 10(8):1798. DOI:10.3390/jcm10081798. PMID:33924265. IF:4,964.
Crovetto F, Crispi F, Llurba E, Pascal R, Larroya M, Trilla C, Camacho M, Medina C, Dobano C, Gomez MD, Figueras F, Gratacos E, Garcia A, Mora J. Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnancy Outcomes: A Population-based Study. CLINICAL INFECTIOUS DISEASES. 2021; 73(10). DOI:10.1093/cid/ciab104. PMID:33556958. IF:20,999.
Diaz SO, Sanchez JL, de Freitas V, Leite A, Barros AS, Reis A. Exploratory analysis of large-scale lipidome in large cohorts: are we any closer of finding lipid-based markers suitable for CVD risk stratification and management?. ANALYTICA CHIMICA ACTA. 2021; 11D42OI:10.1016/j.aca.2020.10.037. PMID:33280696. IF:6,911.
Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF:4,964.
Genua I, Tuneu L, Ramos A, Stantonyonge N, Caimari F, Balague C, Fernandez-Ananin S, Sanchez-Quesada JL, Perez A, Minambres I. Effectiveness of Bariatric Surgery in Patients with the Metabolically Healthy Obese Phenotype. OBESITY SURGERY. 2021; 31(2):517-522. DOI: 10.1007/s11695-020-04967-6. PMID: 32915359. IF:3,479.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Saumoy M, Di S, Perez S, Sanchez JL, Valdivielso JM, Subirana I, Imaz A, Tiraboschi JM, Garcia B, Ordonez J, Benitez S, Podzamczer D, Grau M. Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations. HIV MEDICINE. 2021; 22(7). DOI:10.1111/hiv.13093. PMID:33817938. IF:3,094.
Saumoy M, Sanchez JL, Ordonez J, Podzamczer D. Do All Integrase Strand Transfer Inhibitors Have the Same Lipid Profile? Review of Randomised Controlled Trials in Naive and Switch Scenarios in HIV-Infected Patients. Journal of Clinical Medicine. 2021; 10(16):3456. DOI:10.3390/jcm10163456. PMID:34441755. IF:4,964.
Ullmo J, Cruz M, Sanchez O, Bos L, De la Llama PF, Calero F, Dominguez C, Garrido C, Trilla C, Carreras F, Sionis A, Mora J, Garcia A, Ordonez J, Llurba E. Cardiac dysfunction and remodeling regulated by anti-angiogenic environment in patients with preeclampsia: the ANGIOCOR prospective cohort study protocol. BMC Pregnancy and Childbirth. 2021; 21(1):816. DOI:10.1186/s12884-021-04263-w. PMID:34879854. IF:3,105.

Publicacions 2020

Genua I., Ramos A., Caimari F., Balague C., Sanchez-Quesada J.L., Perez A., Minambres I. (2020) Effects of Bariatric Surgery on HDL Cholesterol. OBES SURG, 30 (5), 1793-1798. IF: 4,1290

CARDIOVASCULAR DISEASES

Cardiovascular Biochemistry

Main lines of research

Atherosclerosis mechanisms

Inflammatory mechanisms induced by LDL(-) on monocytes from patients with diabetes.

Challenges

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Main lines of research

Atherosclerosis mechanisms

Inflammatory mechanisms induced by LDL(-) on monocytes from patients with diabetes.

Challenges

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Institut de recerca de l’hospital de la santa creu i sant pau