Development of fluid biomarkers of synapse degeneration in neurodegenerative diseases and neuropsychiatric disorders.
-omic approaches to understand the molecular basis of synapse degeneration in Alzheimer’s disease.
Pathway-based polygenic risk scores to elucidate the genetic factors underlying Alzheimer’s disease and use of in vitro cell-based assays to assess their function.
Principals Techniques/Expertise
Analysis of proteomic data (SRM/MRM/PRM, LFQ) by PCA, WGCNA, PathFindR, regressions and correlations.
Technical and clinical validation of antibodies and immunoassays in postmortem brain tissue (WB, IHC) and patient-derived biofluids (ELISA/SIMOA).
microRNAomics including miRNA panels and targeted assays.
Synaptosome fractionation from postmortem tissue and isolation of extracellular vesicles.
Massively parallel reporter assays (molecular cloning and in vitro assays).
Multimodal correlative analyses in clinical cohorts.
Fourier-transform infrared spectroscopy analysis in postmortem tissue and patient-derived biofluids.
Pathway-based generation of polygenic risk scores.
nlme modeling of cognitive decline related to genetic risk factors.
Development of fluid biomarkers of synapse degeneration in neurodegenerative diseases and neuropsychiatric disorders.
-omic approaches to understand the molecular basis of synapse degeneration in Alzheimer’s disease.
Pathway-based polygenic risk scores to elucidate the genetic factors underlying Alzheimer’s disease and use of in vitro cell-based assays to assess their function.
Principals Techniques/Expertise
Analysis of proteomic data (SRM/MRM/PRM, LFQ) by PCA, WGCNA, PathFindR, regressions and correlations.
Technical and clinical validation of antibodies and immunoassays in postmortem brain tissue (WB, IHC) and patient-derived biofluids (ELISA/SIMOA).
microRNAomics including miRNA panels and targeted assays.
Synaptosome fractionation from postmortem tissue and isolation of extracellular vesicles.
Massively parallel reporter assays (molecular cloning and in vitro assays).
Multimodal correlative analyses in clinical cohorts.
Fourier-transform infrared spectroscopy analysis in postmortem tissue and patient-derived biofluids.
Pathway-based generation of polygenic risk scores.
nlme modeling of cognitive decline related to genetic risk factors.
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