The Metabolic Bases of Cardiovascular Risk Group of the Sant Pau Hospital Research Institute, is an interdisciplinary and translational research team that works in the field of cardiovascular diseases related to metabolic disorders such as dyslipidemia, diabetes mellitus, obesity, dementias, or hyperhomocysteinemia, among others. The purpose of the group’s different studies and lines of research is to find new targeted therapies and / or biomarkers to reduce cardiovascular risk and Alzheimer’s disease in patients with these metabolic disorders, as well as improve the diagnosis and control of patients.
ESCOLÀ-GIL, JOAN CARLES IR
jescola@santpau.cat
Blanco Vaca, Francisco FGS
Borras Querol, Carla IR
Canyelles Vich, Marina IR
Griñan Gonzalez, Raquel IR
Illana Camara, Francisco Jose FGS
Martinez Figueroa, Susana FGS
Muñoz Neculman, Juan Pablo CIBERDEM
Revilla Senra, Giovanna IR
Roig Martinez, Rosa FGS
Rotllan Vila, Noemi IR
Santos Palacios, David CIBERDEM
Tondo Colomer, Mireia FGS
The Metabolic Bases of Cardiovascular Risk Group of the Sant Pau Hospital Research Institute, is an interdisciplinary and translational research team that works in the field of cardiovascular diseases related to metabolic disorders such as dyslipidemia, diabetes mellitus, obesity, dementias, or hyperhomocysteinemia, among others. The purpose of the group’s different studies and lines of research is to find new targeted therapies and / or biomarkers to reduce cardiovascular risk and Alzheimer’s disease in patients with these metabolic disorders, as well as improve the diagnosis and control of patients.
ESCOLÀ-GIL, JOAN CARLES IR
jescola@santpau.cat
Blanco Vaca, Francisco FGS
Borras Querol, Carla IR
Canyelles Vich, Marina IR
Griñan Gonzalez, Raquel IR
Illana Camara, Francisco Jose FGS
Martinez Figueroa, Susana FGS
Muñoz Neculman, Juan Pablo CIBERDEM
Revilla Senra, Giovanna IR
Roig Martinez, Rosa FGS
Rotllan Vila, Noemi IR
Santos Palacios, David CIBERDEM
Tondo Colomer, Mireia FGS
Becerra-Tomas N., Mena-Sanchez G., Diaz-Lopez A., Martinez-Gonzalez M.A., Babio N., Corella D. et al. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study. EUR J NUTR. 2020; Aug;59(5):2195-2206.doi: 10.1007/s00394-019-02070-w.
IF: 5,614
Bellido V., Perez A. Consequences of COVID-19 on people with diabetes Consecuencias de la COVID-19 sobre las personas con diabetes. ENDOCRINOL DIAB NUTR. 2020;Vol. 67. Núm. 6.Páginas 355-356.
IF: 1,417
Benitez-Amaro A., Revuelta-Lopez E., Bornachea O., Cedo L., Vea A., Herrero L., Roglans N., Soler-Botija C., de Gonzalo-Calvo D., Nasarre L., Camino-Lopez S., Garcia E., Mato E., Blanco-Vaca F., Bayes-Genis A., Sebastian D., Laguna J.C., Serra D., Zorzano A., Escola-Gil J.C., Llorente-Cortes V. (2020) Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity. METABOLISM, 106 (), -.
IF: 8,694
Benito-Vicente A, Uribe KB, Rotllan N, Ramírez CM, Jebari-Benslaiman S, Goedeke L, Canfrán-Duque A, Galicia-García U, Saenz De Urturi D, Aspichueta P, Suárez Y, Fernández-Hernando C, Martín C. miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression. INT J MOL SCI. 2020 Nov 17;21(22):8675. doi: 10.3390/ijms21228675.
IF: 5,923
Bornachea O., Benitez-Amaro A., Vea A., Nasarre L., de Gonzalo-Calvo D., Escola-Gil J.C., Cedo L., Iborra A., Martinez-Martinez L., Juarez C., Camara J.A., Espinet C., Borrell-Pages M., Badimon L., Castell J., Llorente-Cortes V. (2020) Immunization with the Gly1127-Cys1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies. THERANOSTICS, 10 (7), 3263-3280.
IF: 11,556
Canyelles M., Tondo M., Lindholt J.S., Santos D., Fernandez-Alonso I., de Gonzalo-Calvo D. et al. Macrophage cholesterol efflux downregulation is not associated with abdominal aortic aneurysm (AAA) progression. BIOMOLECULES. 2020;10(4): 662. doi: 10.3390/biom10040662.
IF: 4,879
Cedo L., Metso J., Santos D., Garcia-Leon A., Plana N., Sabate-Soler S., Rotllan N., Rivas-Urbina A., Mendez-Lara K.A., Tondo M., Girona J., Julve J., Pallares V., Benitez-Amaro A., Llorente-Cortes V., Perez A., Gomez-Coronado D., Ruotsalainen A.-K., Levonen A.-L., Sanchez-Quesada J.L., Masana L., Kovanen P.T., Jauhiainen M., Lee-Rueckert M., Blanco-Vaca F., Escola-Gil J.C. (2020) LDL receptor regulates the reverse transport of macrophage-derived unesterified cholesterol via concerted action of the HDL-LDL Axis: Insight from mouse models. CIRC RES, 127 (6), 778-792.
IF: 17,367
Cedo L, Fernández-Castillejo S, Rubió L, Metso J, Santos D, Muñoz-Aguayo D, et al. Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo. BIOMEDICINES. 2020;8(8):266.
IF: 6,081
de Gonzalo-Calvo D., Barroeta I., Nan M.N., Rives J., Garzon D., Carmona-Iragui M., Benejam B., Videla L., Fernandez S., Altuna M., Valldeneu S., Blesa R., Lleo A., Blanco-Vaca F., Fortea J., Tondo M. (2020) Evaluation of biochemical and hematological parameters in adults with Down syndrome. SCI REP-UK, 10 (1), -.
IF: 4,379
Delk S.C., Chattopadhyay A., Escola-Gil J.C., Fogelman A.M., Reddy S.T. Apolipoprotein mimetics in cancer. SEMIN CANCER BIOL. 2020 Nov11:S1044-579X(20)30225-X. doi: 10.1016/j.semcancer.2020.11.002.
IF: 15,707
Farràs M, Almanza-Aguilera E, Hernáez Á, Agustí N, Julve J, Fitó M et al. Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence. SEMIN CANCER BIOL. 2020 Nov 26;S1044-579X(20)30247-9. doi: 10.1016/j.semcancer.2020.11.011.
IF: 15,707
Farras M., Canyelles M., Fito M., Escola-Gil J.C. Effects of virgin olive oil and phenol-enriched virgin olive oils on lipoprotein atherogenicity. NUTRIENTS. 2020;12(3): 601.
IF: 5,717
Farràs M, Martinez-Gili L, Portune K, Arranz S, Frost G, Tondo M, et al. Modulation of the Gut Microbiota by Olive Oil Phenolic Compounds: Implications for Lipid Metabolism, Immune System, and Obesity. NUTRIENTS. 2020;12(8): 2200.
IF: 5,717
Genua I., Ramos A., Caimari F., Balague C., Sanchez-Quesada J.L., Perez A., Minambres I. (2020) Effects of Bariatric Surgery on HDL Cholesterol. OBES SURG, 30 (5), 1793-1798.
IF: 4,129
Gutiérrez-Muñoz C, Méndez-Barbero N, Svendsen P, Sastre C, Fernández-Laso V, Quesada P, et al. CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice. FASEB journal: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. 2020;34(11):14960-14976.doi: 10.1096/fj.202000177R.
IF: 5,191
Jayaraman S., Chavez O.R., Perez A., Minambres I., Sanchez-Quesada J.L., Gursky O. (2020) Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia. BBA-MOL CELL BIOL L, 1865 (8), -.
IF: 4,698
Martín-Campos JM, Ruiz-Nogales S, Ibarretxe D, Ortega E, Sánchez-Pujol E, Royuela-Juncadella M, et al. Polygenic Markers in Patients Diagnosed of Autosomal Dominant Hypercholesterolemia in Catalonia: Distribution of Weighted LDL-c-Raising SNP Scores and Refinement of Variant Selection. BIOMEDICINES. 2020;8(9):353.
IF: 6,081
Méndez-Lara KA, Letelier N, Farré N, Diarte-Añazco EMG, Nieto-Nicolau N, Rodríguez-Millán E, et al. Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice. ANTIOXIDANTS (Basel, Switzerland). 2020;9(11):1162.
IF: 6,312
Minambres I., Sanchez-Hernandez J., Cuixart G., Sanchez-Pinto A., Sarroca J., Perez A. (2020) Characterization of the hypertriglyceridemic waist phenotype in patients with type 2 diabetes mellitus in Spain: An epidemiological study Caracterización del fenotipo de cintura hipertrigliceridémica en pacientes con diabetes mellitus tipo 2 en España: un estudio epidemiológico. REV CLIN ESP, (), -.
IF: 1,556
Paz-Graniel I., Babio N., Becerra-Tomas N., Toledo E., Camacho-Barcia L., Corella D. et al. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population. EUR J NUTR. 2020;Oct 30. doi: 10.1007/s00394-020-02415-w.
IF: 5,614
Perez A., Carrasco-Sanchez F.J., Gonzalez C., Segui-Ripoll J.M., Trescoli C., Ena J. et al. Efficacy and safety of insulin glargine 300 U/mL (Gla-300) during hospitalization and therapy intensification at discharge in patients with insufficiently controlled type 2 diabetes: results of the phase IV COBALTA trial. BMJ OPEN DIABETES RES CARE. 2020 Sep;8(1):e001518. doi: 10.1136/bmjdrc-2020-001518.
IF: 3,388
Perez A., Ramos A., Carreras G. Insulin Therapy in Hospitalized Patients. AM J THER. 2020;27(1):e71-e78.
IF: 2,688
Puig N, Miñambres I, Benítez S, Gil P, Grau-Agramunt M, Rivas-Urbina A, et al. Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia. BIOMEDICINES. 2020 Jan 6;8(1):6.doi: 10.3390/biomedicines8010006.
IF: 6,081
Revilla G., Cedo L., Tondo M., Moral A., Perez J.I., Corcoy R., Lerma E., Fuste V., Reddy S.T., Blanco-Vaca F., Mato E., Escola-Gil J.C., LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies (2020) SEMIN CANCER BIOL.
IF: 15,707
Rivas-Urbina A., Rull A., Aldana-Ramos J., Santos D., Puig N., Farre-Cabrerizo N. et al. Subcutaneous administration of apolipoprotein j-derived mimetic peptide d-[113–122]apoj improves LDL and HDL function and prevents atherosclerosis in LDLR-KO mice. BIOMOLECULES. 2020;10(6).
IF: 4,879
Tondo M., Wasek B., Escola-Gil J.C., de Gonzalo-Calvo D., Harmon C., Arning E., et al. Altered brain metabolome is associated with memory impairment in the rTG4510 mouse model of tauopathy. METABOLITES. 2020;10(2): 69.
IF: 4,932
Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, et al. Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB journal: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. 2020;34(9):11816-11837. doi: 10.1096/fj.202000678R.
IF: 5,191
