El Grup de Bases Metabòliques del Risc Cardiovascular de l’Institut de Recerca del Hospital de la Santa Creu i Sant Pau, és un equip interdisciplinari i de recerca traslacional que treballa en el camp de les malalties cardiovasculars relacionades amb alteracions metabòliques como poden ser les dislipèmies, la diabetis mellitus, l’obesitat, les demències, o la hiperhomocisteinèmia, entre d’altres. La finalitat dels diferents estudis i línies d’investigació del grup es trobar noves teràpies dirigides i/o biomarcadors per tal de disminuir el risc cardiovascular i la malaltia d’Alzheimer en pacients amb aquestes alteracions metabòliques, així com millorar el diagnòstic i control dels pacients
ESCOLÀ-GIL, JOAN CARLES IR
jescola@santpau.cat
Blanco Vaca, Francisco FGS
Borras Querol, Carla IR
Canyelles Vich, Marina IR
Griñan Gonzalez, Raquel IR
Illana Camara, Francisco Jose FGS
Martinez Figueroa, Susana FGS
Muñoz Neculman, Juan Pablo CIBERDEM
Revilla Senra, Giovanna IR
Roig Martinez, Rosa FGS
Rotllan Vila, Noemi IR
Santos Palacios, David CIBERDEM
Tondo Colomer, Mireia FGS
El Grup de Bases Metabòliques del Risc Cardiovascular de l’Institut de Recerca del Hospital de la Santa Creu i Sant Pau, és un equip interdisciplinari i de recerca traslacional que treballa en el camp de les malalties cardiovasculars relacionades amb alteracions metabòliques como poden ser les dislipèmies, la diabetis mellitus, l’obesitat, les demències, o la hiperhomocisteinèmia, entre d’altres. La finalitat dels diferents estudis i línies d’investigació del grup es trobar noves teràpies dirigides i/o biomarcadors per tal de disminuir el risc cardiovascular i la malaltia d’Alzheimer en pacients amb aquestes alteracions metabòliques, així com millorar el diagnòstic i control dels pacients
ESCOLÀ-GIL, JOAN CARLES IR
jescola@santpau.cat
Blanco Vaca, Francisco FGS
Borras Querol, Carla IR
Canyelles Vich, Marina IR
Griñan Gonzalez, Raquel IR
Illana Camara, Francisco Jose FGS
Martinez Figueroa, Susana FGS
Muñoz Neculman, Juan Pablo CIBERDEM
Revilla Senra, Giovanna IR
Roig Martinez, Rosa FGS
Rotllan Vila, Noemi IR
Santos Palacios, David CIBERDEM
Tondo Colomer, Mireia FGS
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IF: 5,614
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Benito-Vicente A, Uribe KB, Rotllan N, Ramírez CM, Jebari-Benslaiman S, Goedeke L, Canfrán-Duque A, Galicia-García U, Saenz De Urturi D, Aspichueta P, Suárez Y, Fernández-Hernando C, Martín C. miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression. INT J MOL SCI. 2020 Nov 17;21(22):8675. doi: 10.3390/ijms21228675.
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Canyelles M., Tondo M., Lindholt J.S., Santos D., Fernandez-Alonso I., de Gonzalo-Calvo D. et al. Macrophage cholesterol efflux downregulation is not associated with abdominal aortic aneurysm (AAA) progression. BIOMOLECULES. 2020;10(4): 662. doi: 10.3390/biom10040662.
IF: 4,879
Cedo L., Metso J., Santos D., Garcia-Leon A., Plana N., Sabate-Soler S., Rotllan N., Rivas-Urbina A., Mendez-Lara K.A., Tondo M., Girona J., Julve J., Pallares V., Benitez-Amaro A., Llorente-Cortes V., Perez A., Gomez-Coronado D., Ruotsalainen A.-K., Levonen A.-L., Sanchez-Quesada J.L., Masana L., Kovanen P.T., Jauhiainen M., Lee-Rueckert M., Blanco-Vaca F., Escola-Gil J.C. (2020) LDL receptor regulates the reverse transport of macrophage-derived unesterified cholesterol via concerted action of the HDL-LDL Axis: Insight from mouse models. CIRC RES, 127 (6), 778-792.
IF: 17,367
Cedo L, Fernández-Castillejo S, Rubió L, Metso J, Santos D, Muñoz-Aguayo D, et al. Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo. BIOMEDICINES. 2020;8(8):266.
IF: 6,081
de Gonzalo-Calvo D., Barroeta I., Nan M.N., Rives J., Garzon D., Carmona-Iragui M., Benejam B., Videla L., Fernandez S., Altuna M., Valldeneu S., Blesa R., Lleo A., Blanco-Vaca F., Fortea J., Tondo M. (2020) Evaluation of biochemical and hematological parameters in adults with Down syndrome. SCI REP-UK, 10 (1), -.
IF: 4,379
Delk S.C., Chattopadhyay A., Escola-Gil J.C., Fogelman A.M., Reddy S.T. Apolipoprotein mimetics in cancer. SEMIN CANCER BIOL. 2020 Nov11:S1044-579X(20)30225-X. doi: 10.1016/j.semcancer.2020.11.002.
IF: 15,707
Farràs M, Almanza-Aguilera E, Hernáez Á, Agustí N, Julve J, Fitó M et al. Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence. SEMIN CANCER BIOL. 2020 Nov 26;S1044-579X(20)30247-9. doi: 10.1016/j.semcancer.2020.11.011.
IF: 15,707
Farras M., Canyelles M., Fito M., Escola-Gil J.C. Effects of virgin olive oil and phenol-enriched virgin olive oils on lipoprotein atherogenicity. NUTRIENTS. 2020;12(3): 601.
IF: 5,717
Farràs M, Martinez-Gili L, Portune K, Arranz S, Frost G, Tondo M, et al. Modulation of the Gut Microbiota by Olive Oil Phenolic Compounds: Implications for Lipid Metabolism, Immune System, and Obesity. NUTRIENTS. 2020;12(8): 2200.
IF: 5,717
Genua I., Ramos A., Caimari F., Balague C., Sanchez-Quesada J.L., Perez A., Minambres I. (2020) Effects of Bariatric Surgery on HDL Cholesterol. OBES SURG, 30 (5), 1793-1798.
IF: 4,129
Gutiérrez-Muñoz C, Méndez-Barbero N, Svendsen P, Sastre C, Fernández-Laso V, Quesada P, et al. CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice. FASEB journal: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. 2020;34(11):14960-14976.doi: 10.1096/fj.202000177R.
IF: 5,191
Jayaraman S., Chavez O.R., Perez A., Minambres I., Sanchez-Quesada J.L., Gursky O. (2020) Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia. BBA-MOL CELL BIOL L, 1865 (8), -.
IF: 4,698
Martín-Campos JM, Ruiz-Nogales S, Ibarretxe D, Ortega E, Sánchez-Pujol E, Royuela-Juncadella M, et al. Polygenic Markers in Patients Diagnosed of Autosomal Dominant Hypercholesterolemia in Catalonia: Distribution of Weighted LDL-c-Raising SNP Scores and Refinement of Variant Selection. BIOMEDICINES. 2020;8(9):353.
IF: 6,081
Méndez-Lara KA, Letelier N, Farré N, Diarte-Añazco EMG, Nieto-Nicolau N, Rodríguez-Millán E, et al. Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice. ANTIOXIDANTS (Basel, Switzerland). 2020;9(11):1162.
IF: 6,312
Minambres I., Sanchez-Hernandez J., Cuixart G., Sanchez-Pinto A., Sarroca J., Perez A. (2020) Characterization of the hypertriglyceridemic waist phenotype in patients with type 2 diabetes mellitus in Spain: An epidemiological study Caracterización del fenotipo de cintura hipertrigliceridémica en pacientes con diabetes mellitus tipo 2 en España: un estudio epidemiológico. REV CLIN ESP, (), -.
IF: 1,556
Paz-Graniel I., Babio N., Becerra-Tomas N., Toledo E., Camacho-Barcia L., Corella D. et al. Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population. EUR J NUTR. 2020;Oct 30. doi: 10.1007/s00394-020-02415-w.
IF: 5,614
Perez A., Carrasco-Sanchez F.J., Gonzalez C., Segui-Ripoll J.M., Trescoli C., Ena J. et al. Efficacy and safety of insulin glargine 300 U/mL (Gla-300) during hospitalization and therapy intensification at discharge in patients with insufficiently controlled type 2 diabetes: results of the phase IV COBALTA trial. BMJ OPEN DIABETES RES CARE. 2020 Sep;8(1):e001518. doi: 10.1136/bmjdrc-2020-001518.
IF: 3,388
Perez A., Ramos A., Carreras G. Insulin Therapy in Hospitalized Patients. AM J THER. 2020;27(1):e71-e78.
IF: 2,688
Puig N, Miñambres I, Benítez S, Gil P, Grau-Agramunt M, Rivas-Urbina A, et al. Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia. BIOMEDICINES. 2020 Jan 6;8(1):6.doi: 10.3390/biomedicines8010006.
IF: 6,081
Revilla G., Cedo L., Tondo M., Moral A., Perez J.I., Corcoy R., Lerma E., Fuste V., Reddy S.T., Blanco-Vaca F., Mato E., Escola-Gil J.C., LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies (2020) SEMIN CANCER BIOL.
IF: 15,707
Rivas-Urbina A., Rull A., Aldana-Ramos J., Santos D., Puig N., Farre-Cabrerizo N. et al. Subcutaneous administration of apolipoprotein j-derived mimetic peptide d-[113–122]apoj improves LDL and HDL function and prevents atherosclerosis in LDLR-KO mice. BIOMOLECULES. 2020;10(6).
IF: 4,879
Tondo M., Wasek B., Escola-Gil J.C., de Gonzalo-Calvo D., Harmon C., Arning E., et al. Altered brain metabolome is associated with memory impairment in the rTG4510 mouse model of tauopathy. METABOLITES. 2020;10(2): 69.
IF: 4,932
Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, et al. Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB journal: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. 2020;34(9):11816-11837. doi: 10.1096/fj.202000678R.
IF: 5,191
