Sant Pau - Institut de Recerca

Resum

El Grup de Genòmica de malalties Complexes de l’Institut de recerca de l’Hospital de Sant Pau és un equip interdisciplinari de recerca traslacional, amb experiència en diversos dominis científics: Omics Big Data, Biologia Molecular, Estadística i Bioinformàtica. Per completar les noves línies d’investigació actuals sobre Genòmica de la Trombosi i Medicina de l’Esport, hem integrat recentment el Grup de Biologia Vascular (LABVI) juntament amb l’equip clínic de Cirurgia Vascular i Angiologia de l’Hospital Sant Pau. Això significa noves capacitats per al grup (experiència en biologia cel·lular i tisular, bioquímica de mediadors d’inflamació i anàlisi funcional), creant una línia de recerca vascular única amb una orientació més competitiva i un gran potencial científic. El grup resultant constitueix un equip bàsic i clínic consolidat de recerca translacional i innovadora, amb l’objectiu de transferir tot el nou coneixement que es generi a la investigació òmica i molecular a la pràctica clínica, treballant en les diferents àrees de recerca, amb un enfoc vers la medicina personalitzada i de precisió.

Línies de Recerca

Angiologia i Biologia vascular

Projecte TAGA: Genòmica de l’Aneurisma d’Aorta Abdominal

Trombosi Venosa i Trombosi i Càncer

Projecte GAIT: Anàlisi genètica de la Trombofília idiopàtica.
Projecte RETROVE: Risc de Malaltia Tromboembòlica Venosa.
Projecte ONCOTHROMB: Nous marcadors relacionats amb Trombosi i Càncer.
Projectes AIRTOP i MIRTO: Avaluació del risc individual de Trombosi en pacients oncològics.

Genòmica en Medicina esportiva

Projecte SUMMIT (la salut a l’esport i els seus límits): Maratons i carreres Ultra-trail.

Projecte SHERPA Everest 2017. Exposició a la hipòxia ambiental extrema i el seu efecte sobre la resposta inflamatòria i cardiopulmonar: Impacte biològic, genètic i clínic.
Projecte K2-Xtreme-Genetics. Expedició a el K2. Impacte biològic, genètic i clínic

Areas de Recerca transversal

Bioinformàtica i Epigenètica
Recerca traslacional i Medicina Personalitzada

Reptes científics

Anàlisi de dades d’Omics (Genòmica, transcriptòmica, epigenòmica) en el camp de malalties complexes amb enfocament translacional en cooperació amb grups clínics.
Identificar nous biomarcadors (genètics, epigenètics i / o plasmàtics) que determinin la susceptibilitat a malalties complexes.
Identificar nous mecanismes implicats en el desenvolupament i la progressió de malalties complexes.
Desenvolupament d’algorismes predictius que integrin la informació genètica, biològica i clínica dels pacients (Medicina personalitzada).

Col·laboracions

Amb altres grups del IIB Sant Pau i de l´Hospital de Sant Pau

Thrombosis and Haemostasis, Dr. JC Souto: GAIT, MIRTO, RETROVE Projects.
Clinical Hematology, Dr. J Sierra: MIRTO Project.
Neurology, Dr. J. Marti: MIRTO Project. Elena Jimenez: Lipoproteic biomarkers. ICTUS.
Otorhinolaryngology. Dr. M Quer and Dr. X Leon. Prediction of response to head and neck cancer.
Regulatory Mechanisms of Cardiovascular Remodeling. Dra. C. Rodriguez and Dra. M Galán.
Participation en CIBERCV (CIBER of cardiovascular diseases). Dr. J González.
General and Digestive Surgery. Dra. C Balaguer
Clinical Pharmacology. Dra. MA Mangues and Dra. M Gomis. AIRTOP Project.
Neumology Service, Dr. O Sibila: SUMMIT, SHERPA Projects.

Externes

Clinical Oncology Department, Hospital Gregorio Marañón, Madrid,Dr. A Muñoz: ONCOTHROMB, AIRTOP Projects.
Clinical Department of Hematology and Hemostasis. University of Wien, Austria. Dra. I Pabinger. ONCOTHROMB, MIRTO Projects.
Dr. J Schwenk. SciLifeLab, Sweeden: GAIT Project
Department of Genetics, University of Genève, Switzerland, Dr. M Dermitzakis and Dr. A Viñuela: GAIT Project.
Institute of Biological Psychiatry, Sankt Hans Hospital. Roskilde, Denmark, Dr. A Buil: Bioinformatics of Complex diseases, GAIT Project.
Laboratory Haematology, Hospital Timone Marseille, France, Dr. P Morange: GAIT, VEREMA Projects.
INSERM UMR_S1219 – Bordeaux Public Health Center. Bordeaux, France. Dr. DA Tregouet: GAIT, VEREMA Projects.
Haematology Department, Karolinska Hospital, Sweden, Dr. J Odeberg: VEREMA Project.
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid. Dr. JM Redondo.
Hospital Clínic de Barcelona. Otorhinolaryngology Service. Prediction of response to head and neck cancer. Dr. FX Avilés.
Hospital Vall d’Hebron, Barcelona. Vascular Surgery Service. Dr. S Bellmunt.
Bac de Sang i Teixits (BST). Dr. F Vidal.
Centre de Recerca en Enginyeria Biomèdica, Universitat Politècnica de Catalunya, Barcelona, Dr. A Perera: SUMMIT Project.
CAR, Centre d’Alt Rendiment Sportiu, Sant Cugat. Dr. F Drobnic: Sport Medicine Projects.
CHARGE, International network consortium. Hemostatic factors studies.
GIANT, International network consortium. Anthropometric factors studies.
GLGC, International network consortium. Lipidic factors research.

With Biopharma companies

GenIncode. Development of Genetic Diagnostics in Thrombosis.
Leo-Pharma. Prediction of Thrombosis Risk in cancer patients.

Coordinació del grup

SORIA FERNANDEZ, JOSE MANUEL IR
jsoria@santpau.cat

Membres

Alcolea Ruiz, Sonia IR
Aloy Ortiz, Carme ENTITAT EXTERNA
Camacho Perez De Madrid, Maria Mercedes IR
Diez Ahijado, Laia IR
Dilme Muñoz, Jaume Felix FGS
Escudero Rodriguez, Jose Roman FGS
Fite Matamoros, Joan FGS
Lloret Cano, Maria Dolores ENTITAT EXTERNA
Lobato Delgado, Barbara IR
Martinez Perez, Angel IR
Romero Carro, Josep Maria FGS
Sabater Lleal, Maria IR
Soto Carricas, Begoña Dolores FGS
Temprano Sagrera, Gerard IR

Publicacions 2021

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater M, Naderi E, Seppala I, Shah T, Singhal G, et al., CHARGE Inflammation Working GRP. Genome-wide association study of circulating interleukin 6 levels identifies novel loci. HUMAN MOLECULAR GENETICS. 2021; 30(5). DOI:10.1093/hmg/ddab023. PMID:33517400. IF:5,121.
Aviles-Jurado FX, Munoz C, Meler C, Flores JC, Guma J, Benaiges E, Mora J, Camacho M, Leon X, Vilaseca I, Terra X. Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(5):1585-1594. DOI: 10.1007/s00405-020-06240-z. PMID: 32737645. IF:3,236.
Bastos M, Ortiz J, Pradillo V, Salas E, Marinez C, Munoz A, Buno I, Diez JL, Soria JM, Izquierdo CP. Incorporating genetic and clinical data into the prediction of thromboembolism risk in patients with lymphoma. Cancer Medicine. 2021; 10(21). DOI:10.1002/cam4.4280. PMID:34598309. IF:4,711.
Bonfill X, Quintana MJ, Escudero JR, Miralles M, Fite J, Mikelarena E, Castejon B, Garnica M, De Valderrama IF, Rodriguez A, Pijoan JI, Bellmunt S. Appropriateness of surgery performed for abdominal aortic aneurysm at tertiary hospitals in Spain. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04654-X. PMID:34060282. IF:2,103.
Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Ellervik C, Mora S, Kus A, Asvold B, Marouli E, Deloukas P, Sterenborg RBTM, Teumer A, Burgess S, Sabater M, Huffman J, Johnson AD, Tregouet DA, Smith NL, Medici M, DeVries PS, Chasman DI, Kjaergaard AD. Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study. THYROID. 2021; 31(9). DOI:10.1089/thy.2021.0055. PMID:34210154. IF:6,506.
Fite J, Gayarre R, Puig T, Zamora S, Escudero JR, Roca JS, Bellmunt S. Feasibility and Efficiency Study of a Population-Based Abdominal Aortic Aneurysm Screening Program in Men and Women in Spain. ANNALS OF VASCULAR SURGERY. 2021; 73. DOI:10.1016/j.avsg.2020.11.042. PMID:33387620. IF:1,607.
Fite J, Gimenez E, Soto B, Artigas V, Escudero JR, Bellmunt S, Espallargues M. Systematic review on abdominal aortic aneurysm screening cost-efficiency and methodological quality assessment. INTERNATIONAL ANGIOLOGY. 2021; 40(1). DOI:10.23736/S0392-9590.20.04547-2. PMID:33086780. IF:2,103.
Goncalves G, Gil D, Tello C, Tenezaca X, Marrero C, Puig T, Gayarre R, Fite J, Bellmunt S. Prevalence of Peripheral Arterial Disease and Associated Vascular Risk Factors in 65-Years-Old People of Northern Barcelona. Journal of Clinical Medicine. 2021; 10(19):4467. DOI:10.3390/jcm10194467. PMID:34640483. IF:4,964.
Goumidi L, Thibord F, Wiggins KL, Li RF, Brown MR, Vlieg AV, Souto JC, Soria JM, Ibrahim M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook DO, Deleuze JF, Johnson A, de Vries PS, Sabater M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Tregouet DA, Morange PE. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. BLOOD. 2021; 137(17). DOI:10.1182/blood.2020008997. PMID:33512453. IF:25,476.
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, et al. [Sabater M]. The power of genetic diversity in genome-wide association studies of lipids. NATURE. 2021; 600(7890). DOI:10.1038/s41586-021-04064-3. PMID:34887591. IF:69,504.
Guo YJ, Rist PM, Sabater M, de Vries P, Smith N, Ridker PM, Kurth T, Chasman DI. Association Between Hemostatic Profile and Migraine A Mendelian Randomization Analysis. NEUROLOGY. 2021; 96(20). DOI:10.1212/WNL.0000000000011931. PMID:33795393. IF:11,800.
Leon X, Venegas M, Pujol A, Bulboa C, Llansana A, Casasayas M, Quer M, Camacho M. Predictive value of transcriptional expression of Kruppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clinical & Translational Oncology. 2021; 23(12). DOI:10.1007/s12094-021-02651-4. PMID:34061320. IF:3,340.
Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
Paloschi V, Sabater M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab088. PMID:33729461. IF:13,081.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Sanchez L, Fite J, Peypoch O, Moreno J, Jubert Q, Carricas BS, Dilme JF, Escudero JR. Preoperative geriatric assessment, a promising tool to improve outcomes in aortic pathology interventions. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04643-5. PMID:33913311. IF:2,103.
Small AM, Huffman JE, Klarin D, Sabater M, Lynch JA, Assimes TL, Sun YV, Miller D, Freiberg MS, Morrison AC, Rader DJ, Wilson PWF, Cho K, Tsao PS, Chang KM, Smith NL, O’Donnell CJ, de Vries PS, Damrauer SM, Cohorts Heart Aging Res Genomic &, VA Million Veteran P. Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021; 41(1). DOI:10.1161/ATVBAHA.119.313847. PMID:32847391. IF:10,514.
Thibord F, Song C, Pattee J, Rodriguez B, Chen MH, O’Donnell CJ, Kleber ME, Delgado GE, Guo XQ, Yao J, Taylor KD, Ozel AB, Brody JA, McKnight B, Gyorgy B, Simonsick E, Leonard HL, Carrasquilla GD, Guindo M, Silveira A, Temprano G, Yanek LR, Becker DM, Mathias RA, Becker LC, Raffield LM, Kilpelainen TO, Grarup N, Pedersen O, Hansen T, et al. [Sabater M]. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021; 19(8). DOI:10.1111/jth.15345. PMID:33876560. IF:16,036.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

Publicacions 2020

Bennett J.A., Mastrangelo M.A., Ture S.K., Smith C.O., Loelius S.G., Berg R.A., Shi X., Burke R.M., Spinelli S.L., Cameron S.J., Carey T.E., Brookes P.S., Gerszten R.E., Sabater-Lleal M., de Vries P.S., Huffman J.E., Smith N.L., Morrell C.N., Lowenstein C.J. (2020) The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function. NAT COMMUN, 11 (1), -. IF: 14,9190

Fité J, Gimenez E, Soto B, Artigas V, Escudero JR, Bellmunt S, et al. Systematic review on abdominal aortic aneurysm screening cost-efficiency and methodological quality assessment. INT ANGIOL 2020;39:000-000. DOI: 10.23736/S0392-9590.20.04547-2. PMID: 33086780. IF: 2,789

Georgakis MK, Malik R, Gill D, Franceschini N, Sudlow CLM, Dichgans M; INVENT Consortium,CHARGE Inflammation Working Group. Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study. CIRC GENOM PRECIS MED. 2020 Jun;13(3):e002872. DOI: 10.1161/CIRCGEN.119.002872. Epub 2020 May 12. PMID: 32397738; PMCID: PMC7299212. IF: 6,054

Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, van Hylckama Vlieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Daian-Bacq D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison A, Mook-Kanamori DO, Deleuze JF, Johnson AD, de Vries PS, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Tregouet D, Morange PE. Association of ABO haplotypes with the risk of venous thrombosis: impact on disease risks estimation. BLOOD. 2020 Dec 22:blood.2020008997. DOI: 10.1182/blood.2020008997. Epub ahead of print. PMID: 33512453. IF: 22,113

Kim-Hellmuth S, Aguet F, Oliva M, Muñoz-Aguirre M, Kasela S, Wucher V, Castel S, Hamel A, Viñuela A, Roberts A, Mangul A, Wen X, Wang G, Barbeira A, Garrido-Martín D, Nadel B, Zou Y, Bonazzola R, Quan J, Brown A, Martinez-Perez A, Soria JM, Getz G, Dermitzakis E, Small S, Stephens M, Xi H, Kyung Im H, Guigó R, Segrè A, Stranger B, Ardlie K, Lappalainen T. Cell type specific genetic regulation of gene expression across human tissues. SCIENCE 2020 Sep 11;369(6509):eaaz8528. DOI: 10.1126/science.aaz8528. PMID: 32913075. IF: 47,728

Méndez-Lara KA, Letelier N, Farré N, Diarte-Añazco EMG, Nieto-Nicolau N, Rodríguez-Millán E, Santos D, Pallarès V, Escolà-Gil JC, Vázquez Del Olmo T, Lerma E, Camacho M, Casaroli-Marano RP, Valledor AF, Blanco-Vaca F, Julve J. Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice. ANTIOXIDANTS (BASEL). 2020 Nov 21;9(11):1162. DOI: 10.3390/antiox9111162. PMID: 33233455; PMCID: PMC7700561. IF: 6,312

Navas-Madroñal M, Castelblanco E, Camacho M, Consegal M, Ramirez-Morros A, Sarrias MR, Perez P, Alonso N, Galán M, Mauricio D. Role of the Scavenger Receptor CD36 in Accelerated Diabetic Atherosclerosis. INT J MOL SCI. 2020 Oct 5;21(19):7360. DOI: 10.3390/ijms21197360. PMID: 33028031; PMCID: PMC7583063. IF: 5,923

Oliva M, Muñoz-Aguirre M, Kim-Hellmuth S, Wucher V, Gewirtz A, Cotter D, Parsana P, Kasela S, Balliu B, Viñuela A, Castel S, Mohammadi P, Aguet F, Zou Y, Khramtsova E, Skol A, Garrido-Martín D, Reverter F, Brown A, et al. The impact of sex on gene expression across human tissues. SCIENCE 2020. Sep 11;369(6509):eaba3066. DOI: 10.1126/science.aba3066. PMID: 32913072. IF: 47,728

Permanyer E., Munoz-Guijosa C., Padro J.-M., Ginel A., Montiel J., Sanchez-Quesada J.L., Vila L., Camacho M. (2020) Mini-extracorporeal circulation surgery produces less inflammation than off-pump coronary surgery. EUR J CARDIO-THORAC, 57 (3), 496-503. IF: 4,1910

Peypoch O, Paüls-Vergés F, Vázquez-Santiago M, Dilme J, Romero J, Giner J, Plaza V, Escudero JR, Soria JM, Camacho M, Sabater-Lleal M. The TAGA Study: A Study of Factors Determining Aortic Diameter in Families at High Risk of Abdominal Aortic Aneurysm Reveal Two New Candidate Genes. J CLIN MED. 2020 Apr 24;9(4). pii: E1242. DOI: 10.3390/jcm9041242. PubMed PMID: 32344696. IF: 4,241

Rodriguez-Rius A., Lopez S., Martinez-Perez A., Souto J.C., Soria J.M. (2020) Identification of a Plasma MicroRNA Profile Associated with Venous Thrombosis. ARTERIOSCL THROM VAS, (), 1392-1399. IF: 8,3110

Rodriguez-Rius A., Martinez-Perez A., Lopez S., Sabater-Lleal M., Souto J.C., Soria J.M. (2020) Expression of microRNAs in human platelet-poor plasma: analysis of the factors affecting their expression and association with proximal genetic variants. EPIGENETICS-US, 15 (12), 1396-1406. IF: 4,5280

Rykaczewska U., Suur B.E., Rohl S., Razuvaev A., Lengquist M., Sabater-Lleal M., van der Laan S.W., Miller C.L., Wirka R.C., Kronqvist M., Gonzalez Diez M., Vesterlund M., Gillgren P., Odeberg J., Lindeman J.H., Veglia F., Humphries S.E., de Faire U., Baldassarre D., Tremoli E., Lehtio J., Hansson G.K., Paulsson-Berne G., Pasterkamp G., Quertermous T., Hamsten A., Eriksson P., Hedin U., Matic L. (2020) PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling. CIRC RES, 126 (5), 571-585. IF: 17,3670

Small A.M., Huffman J.E., Klarin D., Sabater-Lleal M., Lynch J.A., Assimes T.L., Sun Y.V., Miller D., Freiberg M.S., Morrison A.C., Rader D.J., Wilson P.W.F., Cho K., Tsao P.S., Chang K.-M., Smith N.L., O’Donnell C.J., De Vries P.S., Damrauer S.M., Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease - Brief Report (2020) ARTERIOSCL THROM VAS, 380-386. IF: 8,311

Memoria IIB-Sant-Pau-2020- Genómica

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Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk. Lopez S, Martinez-Perez A, Rodriguez-Rius A, Viñuela A, Brown AA, Martin-Fernandez L, Vilalta N, Arús M, Panousis NI, Buil A, Sabater-Lleal M, Souto JC, Dermitzakis ET, Soria JM. Thromb Haemost. 2022 Mar 10. doi: 10.1055/s-0041-1742169. Online ahead of print. PMID: 35272364. IF: 6.681. Q1.
Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Puig N, Camps-Renom P, Camacho M, Aguilera-Simón A, Jiménez-Altayó F, Fernández-León A, Marín R, Martí-Fàbregas J, Sánchez-Quesada JL, Jiménez-Xarrié E, Benitez S. Transl Stroke Res. 2022 Oct;13(5):745-756. doi: 10.1007/s12975-022-01002-x. Epub 2022 Mar 2. PMID: 35237947. IF:6.8. Q1
TMAO and gut microbial-derived metabolites TML and γBB are not associated with thrombotic risk in patients with venous thromboembolism. Marina Canyelles, Melania Plaza, Noemí Rotllan, Dolors Llobet, Josep Julve, Sergi Mojal, Maribel Diaz-Ricart, José Manuel Soria, Joan Carles Escolà-Gil, Mireia Tondo, Francisco Blanco-Vaca, Joan Carles Souto. Journal of Clinical Medicine. 2022 Mar 4; 11(5):1425. doi: 10.3390/jcm11051425. PMID: 35268516. IF: 4.964. Q2.
Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. Carla Meler-Claramonte, Francesc Xavier Avilés-Jurado, Isabel Vilaseca, Ximena Terra, Paloma Bragado, Gemma Fuster, Xavier León Vintró, Mercedes Camacho. Cancers (Basel) 2022 Apr 30;14(9):2259. doi: 10.3390/cancers14092259. PMID: 35565388. IF:6.575. Q1.
Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. Corrochano M, Acosta-Isaac R, Mojal S, Miqueleiz S, Rodriguez D, Quijada-Manuitt MA, Fraga E, Castillo-Ocaña M, Amaro-Hosey K, Albiol N, Soria JM, Antonijoan RM, Souto JC. J Thromb Thrombolysis. 2022 Jan;53(1):96-102. doi: 10.1007/s11239-021-02507-2. Epub 2021 Jun 17. PMID: 34138399 IF: 5.221. Q2
Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. Corrochano M, Acosta-Isaac R, Mojal S, Miqueleiz S, Rodriguez D, Quijada-Manuitt MA, Fraga E, Castillo-Ocaña M, Amaro-Hosey K, Albiol N, Soria JM, Antonijoan RM, Souto JC. J Thromb Thrombolysis. 2022 Jan;53(1):96-102. doi: 10.1007/s11239-021-02507-2. Epub 2021 Jun 17. PMID: 34138399 IF: 5.221. Q2.
Incorporating Genetic and Clinical Data into the Prediction of Thromboembolism Risk in Patients with Lymphoma. Bastos Oreiro M, Ortiz J, Pradillo V, Martínez Laperche C, Salas E, Buño I, Díez JL, Soria JM, Pascual Izquierdo C. Cancer Medicine. 2021 Oct 1. doi: 10.1002/cam4.4280. Online ahead of print. PMID: 34598309. IF: 4.452. Q2
Association of ABO haplotypes with the risk of venous thrombosis: impact on disease risks estimation. Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, Van Hylckama Vieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Dainan D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison, AC, Mook-Kanamori DO, Deleuze JF, Johnson A, De Vries P, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal F, Chasman DI, Tré gouët DA, Morange PE. Blood. 2021 Apr 29;137(17):2394-2402 PMID: 33512453. IF: 17.794. D1
Predictive Ability of a Clinical-Genetic Risk Score for Venous Thromboembolism iNorthern and Southern European Populations. Salas E, Farm M, Pich S, Onelöv L, Guillen K, Ortega I, Antovic JP, Soria JM. Thrombosis and Haemostasis. 2021. TH Open. 2021 Jul 8;5(3):e303-e311. doi: 10.1055/s-0041-1729626. eCollection 2021 Jul. PMID: 34263111. IF: 5.249. Q1
Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19. Corrochano M, Acosta-Isaac R, Mojal S, Miqueleiz S, Rodriguez D, Quijada-Manuitt MA, Fraga E, Castillo-Ocaña M, Amaro-Hosey K, Albiol N, Soria JM, Antonijoan RM, Souto JC. J Thromb Thrombolysis. 2021 Jun 17. doi: 10.1007/s11239-021-02507-2. Online ahead of print. PMID: 34138399. IF: 2.054. Q3
Cell type specific genetic regulation of gene expression across human tissues. Kim-Hellmuth S, Aguet F, Oliva M, Muñoz-Aguirre M, Kasela S, Wucher V, Castel S, Hamel A, Viñuela A, Roberts A, Mangul A, Wen X, Wang G, Barbeira A, Garrido-Martín D, Nadel B, Zou Y, Bonazzola R, Quan J, Brown A, Martinez-Perez A, Soria JM, Getz G, Dermitzakis E, Small S, Stephens M, Xi H, Kyung Im H, Guigó R, Segrè A, Stranger B, Ardlie K, Lappalainen T. Science, Sept 2020 (DOI: https://doi.org/10.1126/science.aaz8528 ). IF: 41.485. D1.
The impact of sex on gene expression across human tissues. Oliva M, Muñoz-Aguirre M, Kim-Hellmuth S, Wucher V, Gewirtz A, Cotter D, Parsana P, Kasela S, Balliu B, Viñuela A, Castel S, Mohammadi P, Aguet F, Zou Y, Khramtsova E, Skol A, Garrido-Martín D, Reverter F, Brown A, Evans P, Gamazon E, Payne A, Bonazzola R, Barbeira A, Hamel A, Martinez-Perez A, Soria JM, Pierce B, Stephens M, Eskin E, Dermitzakis E, Segrè A, Kyung Im H, Engelhardt B, Ardlie K, Montgomery S, Battle A, Lappalainen T, Guigó R, Stranger B. Science, Sept 2020 (https://doi.org/10.1126/science.aba3066). IF: 41.485. D1.
Expression of microRNAs in human platelet-poor plasma: analysis of the factors affecting their expression and association with proximal genetic variants. Rodriguez-Rius A, Martinez-Perez A, López S, Sabater-Lleal M, Souto JC, Soria JM. Epigenetics. 2020 Jun 16. doi: 10.1080/15592294.2020.1783497. Online ahead of print. PMID: 32543954. IF: 4.173. Q1.
The TAGA Study: A Study of Factors Determining Aortic Diameter in Families at High Risk of Abdominal Aortic Aneurysm Reveal Two New Candidate Genes. Peypoch O, Paüls-Vergés F, Vázquez-Santiago M, Dilme J, Romero J, Giner J, Plaza V, Escudero JR, Soria JM, Camacho M, Sabater-Lleal M. J Clin Med. 2020 Apr 24;9(4). pii: E1242. doi: 10.3390/jcm9041242. PMID: 32344696. IF: 5.688, D1Identification of a Plasma
MicroRNA Profile Associated With Venous Thrombosis. Rodriguez-Rius A, Lopez S, Martinez-Perez A, Souto JC, Soria JM. Arterioscler Thromb Vasc Biol. 2020 Mar 12:ATVBAHA120314092. doi: 10.1161/ATVBAHA.120.314092. [Epub ahead of print].PMID: 32160777. IF: 6.618, D1

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology. de Vries PS, Sabater-Lleal M, Huffman JE, Marten J, Song C, Pankratz N, Bartz TM, de Haan HG, Delgado GE, Eicher JD, Martinez-Perez A, Ward-Caviness CK, Brody JA, Chen MH, de Maat MPM, Frånberg M, Gill D, Kleber ME, Rivadeneira F, Soria JM, Tang W, Tofler GH, Uitterlinden AG, van Hylckama Vlieg A, Seshadri S, Boerwinkle E, Davies NM, Giese AK, Ikram MK, Kittner SJ, McKnight B, Psaty BM, Reiner AP, Sargurupremraj M, Taylor KD, Fornage M, Hamsten A, März W, Rosendaal FR, Souto JC, Dehghan A, Johnson AD, Morrison AC, O’Donnell CJ, Smith NL. Blood. 2019 Jan 14. pii: blood-2018-05-849240. doi: 10.1182/blood-2018-05-849240. [Epub ahead of print]. PMID: 30642921, D1. IF: 16.562
Breathless and dying on Mount Everest. Garrido E, Soria JM, Salisbury R. Lancet Respir Med. 2019 Nov;7(11):e36 PMID: 31645281. IF: 22.992. D1.

Genome-wide association trans-ethnic meta-analyses identifies novel associations regulating coagulation Factor VIII and von Willebrand Factor plasma level. Sabater-Lleal M et al. INVENT Consortium; MEGASTROKE consortium of the International Stroke Genetics Consortium (ISGC). Circulation. 2019 Jan 29;139(5):620-635. doi: 10.1161/CIRCULATIONAHA.118.034532. PMID: 30586737. IF: 23.054. D1.
Multivariable clinical-genetic risk model for predicting venous thromboembolic events in patients with cancer. Muñoz Martín A, Ortega I, Font C, Pachón V, Castellón V, Martínez-Marín V, Salgado M, Martínez de Castro E, Calzas J, Rupérez A, Souto JC, Martín M, Salas E, Soria JM. Br J Cancer. 2018 Mar 28. doi: 10.1038/s41416-018-0027-8. [Epub ahead of print]. PMID: 29588512. IF: 5.416. Q1.

presentació

Resum

Línies de Recerca

Angiologia i Biologia vascular

Projecte TAGA: Genòmica de l’Aneurisma d’Aorta Abdominal

Trombosi Venosa i Trombosi i Càncer

Projecte GAIT: Anàlisi genètica de la Trombofília idiopàtica.
Projecte RETROVE: Risc de Malaltia Tromboembòlica Venosa.
Projecte ONCOTHROMB: Nous marcadors relacionats amb Trombosi i Càncer.
Projectes AIRTOP i MIRTO: Avaluació del risc individual de Trombosi en pacients oncològics.

Genòmica en Medicina esportiva

Projecte SUMMIT (la salut a l’esport i els seus límits): Maratons i carreres Ultra-trail.

Projecte SHERPA Everest 2017. Exposició a la hipòxia ambiental extrema i el seu efecte sobre la resposta inflamatòria i cardiopulmonar: Impacte biològic, genètic i clínic.
Projecte K2-Xtreme-Genetics. Expedició a el K2. Impacte biològic, genètic i clínic

Areas de Recerca transversal

Bioinformàtica i Epigenètica
Recerca traslacional i Medicina Personalitzada

Reptes científics

Anàlisi de dades d’Omics (Genòmica, transcriptòmica, epigenòmica) en el camp de malalties complexes amb enfocament translacional en cooperació amb grups clínics.
Identificar nous biomarcadors (genètics, epigenètics i / o plasmàtics) que determinin la susceptibilitat a malalties complexes.
Identificar nous mecanismes implicats en el desenvolupament i la progressió de malalties complexes.
Desenvolupament d’algorismes predictius que integrin la informació genètica, biològica i clínica dels pacients (Medicina personalitzada).

Col·laboracions

Amb altres grups del IIB Sant Pau i de l´Hospital de Sant Pau

Thrombosis and Haemostasis, Dr. JC Souto: GAIT, MIRTO, RETROVE Projects.
Clinical Hematology, Dr. J Sierra: MIRTO Project.
Neurology, Dr. J. Marti: MIRTO Project. Elena Jimenez: Lipoproteic biomarkers. ICTUS.
Otorhinolaryngology. Dr. M Quer and Dr. X Leon. Prediction of response to head and neck cancer.
Regulatory Mechanisms of Cardiovascular Remodeling. Dra. C. Rodriguez and Dra. M Galán.
Participation en CIBERCV (CIBER of cardiovascular diseases). Dr. J González.
General and Digestive Surgery. Dra. C Balaguer
Clinical Pharmacology. Dra. MA Mangues and Dra. M Gomis. AIRTOP Project.
Neumology Service, Dr. O Sibila: SUMMIT, SHERPA Projects.

Externes

Clinical Oncology Department, Hospital Gregorio Marañón, Madrid,Dr. A Muñoz: ONCOTHROMB, AIRTOP Projects.
Clinical Department of Hematology and Hemostasis. University of Wien, Austria. Dra. I Pabinger. ONCOTHROMB, MIRTO Projects.
Dr. J Schwenk. SciLifeLab, Sweeden: GAIT Project
Department of Genetics, University of Genève, Switzerland, Dr. M Dermitzakis and Dr. A Viñuela: GAIT Project.
Institute of Biological Psychiatry, Sankt Hans Hospital. Roskilde, Denmark, Dr. A Buil: Bioinformatics of Complex diseases, GAIT Project.
Laboratory Haematology, Hospital Timone Marseille, France, Dr. P Morange: GAIT, VEREMA Projects.
INSERM UMR_S1219 – Bordeaux Public Health Center. Bordeaux, France. Dr. DA Tregouet: GAIT, VEREMA Projects.
Haematology Department, Karolinska Hospital, Sweden, Dr. J Odeberg: VEREMA Project.
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid. Dr. JM Redondo.
Hospital Clínic de Barcelona. Otorhinolaryngology Service. Prediction of response to head and neck cancer. Dr. FX Avilés.
Hospital Vall d’Hebron, Barcelona. Vascular Surgery Service. Dr. S Bellmunt.
Bac de Sang i Teixits (BST). Dr. F Vidal.
Centre de Recerca en Enginyeria Biomèdica, Universitat Politècnica de Catalunya, Barcelona, Dr. A Perera: SUMMIT Project.
CAR, Centre d’Alt Rendiment Sportiu, Sant Cugat. Dr. F Drobnic: Sport Medicine Projects.
CHARGE, International network consortium. Hemostatic factors studies.
GIANT, International network consortium. Anthropometric factors studies.
GLGC, International network consortium. Lipidic factors research.

With Biopharma companies

GenIncode. Development of Genetic Diagnostics in Thrombosis.
Leo-Pharma. Prediction of Thrombosis Risk in cancer patients.

equip

Coordinació del grup

SORIA FERNANDEZ, JOSE MANUEL IR
jsoria@santpau.cat

Membres

producció científica

Publicacions 2021

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater M, Naderi E, Seppala I, Shah T, Singhal G, et al., CHARGE Inflammation Working GRP. Genome-wide association study of circulating interleukin 6 levels identifies novel loci. HUMAN MOLECULAR GENETICS. 2021; 30(5). DOI:10.1093/hmg/ddab023. PMID:33517400. IF:5,121.
Aviles-Jurado FX, Munoz C, Meler C, Flores JC, Guma J, Benaiges E, Mora J, Camacho M, Leon X, Vilaseca I, Terra X. Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(5):1585-1594. DOI: 10.1007/s00405-020-06240-z. PMID: 32737645. IF:3,236.
Bastos M, Ortiz J, Pradillo V, Salas E, Marinez C, Munoz A, Buno I, Diez JL, Soria JM, Izquierdo CP. Incorporating genetic and clinical data into the prediction of thromboembolism risk in patients with lymphoma. Cancer Medicine. 2021; 10(21). DOI:10.1002/cam4.4280. PMID:34598309. IF:4,711.
Bonfill X, Quintana MJ, Escudero JR, Miralles M, Fite J, Mikelarena E, Castejon B, Garnica M, De Valderrama IF, Rodriguez A, Pijoan JI, Bellmunt S. Appropriateness of surgery performed for abdominal aortic aneurysm at tertiary hospitals in Spain. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04654-X. PMID:34060282. IF:2,103.
Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Ellervik C, Mora S, Kus A, Asvold B, Marouli E, Deloukas P, Sterenborg RBTM, Teumer A, Burgess S, Sabater M, Huffman J, Johnson AD, Tregouet DA, Smith NL, Medici M, DeVries PS, Chasman DI, Kjaergaard AD. Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study. THYROID. 2021; 31(9). DOI:10.1089/thy.2021.0055. PMID:34210154. IF:6,506.
Fite J, Gayarre R, Puig T, Zamora S, Escudero JR, Roca JS, Bellmunt S. Feasibility and Efficiency Study of a Population-Based Abdominal Aortic Aneurysm Screening Program in Men and Women in Spain. ANNALS OF VASCULAR SURGERY. 2021; 73. DOI:10.1016/j.avsg.2020.11.042. PMID:33387620. IF:1,607.
Fite J, Gimenez E, Soto B, Artigas V, Escudero JR, Bellmunt S, Espallargues M. Systematic review on abdominal aortic aneurysm screening cost-efficiency and methodological quality assessment. INTERNATIONAL ANGIOLOGY. 2021; 40(1). DOI:10.23736/S0392-9590.20.04547-2. PMID:33086780. IF:2,103.
Goncalves G, Gil D, Tello C, Tenezaca X, Marrero C, Puig T, Gayarre R, Fite J, Bellmunt S. Prevalence of Peripheral Arterial Disease and Associated Vascular Risk Factors in 65-Years-Old People of Northern Barcelona. Journal of Clinical Medicine. 2021; 10(19):4467. DOI:10.3390/jcm10194467. PMID:34640483. IF:4,964.
Goumidi L, Thibord F, Wiggins KL, Li RF, Brown MR, Vlieg AV, Souto JC, Soria JM, Ibrahim M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook DO, Deleuze JF, Johnson A, de Vries PS, Sabater M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Tregouet DA, Morange PE. Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation. BLOOD. 2021; 137(17). DOI:10.1182/blood.2020008997. PMID:33512453. IF:25,476.
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, et al. [Sabater M]. The power of genetic diversity in genome-wide association studies of lipids. NATURE. 2021; 600(7890). DOI:10.1038/s41586-021-04064-3. PMID:34887591. IF:69,504.
Guo YJ, Rist PM, Sabater M, de Vries P, Smith N, Ridker PM, Kurth T, Chasman DI. Association Between Hemostatic Profile and Migraine A Mendelian Randomization Analysis. NEUROLOGY. 2021; 96(20). DOI:10.1212/WNL.0000000000011931. PMID:33795393. IF:11,800.
Leon X, Venegas M, Pujol A, Bulboa C, Llansana A, Casasayas M, Quer M, Camacho M. Predictive value of transcriptional expression of Kruppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clinical & Translational Oncology. 2021; 23(12). DOI:10.1007/s12094-021-02651-4. PMID:34061320. IF:3,340.
Mendez KA, Rodriguez E, Sebastian D, Blanco R, Camacho M, Nan MN, Diarte E, Mato E, Lope S, Roglans N, Laguna JC, Alonso N, Mauricio D, Zorzano A, Villarroya F, Villena JA, Blanco F, Julve J. Nicotinamide Protects Against Diet-Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. MOLECULAR NUTRITION & FOOD RESEARCH. 2021; 65(11):2100111. DOI:10.1002/mnfr.202100111. PMID:33870623. IF:6,575.
Paloschi V, Sabater M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab088. PMID:33729461. IF:13,081.
Rotllan N, Camacho M, Tondo M, Diarte E, Canyelles M, Mendez KA, Benitez S, Alonso N, Mauricio D, Escola JC, Blanco F, Julve J. Therapeutic Potential of Emerging NAD plus -Increasing Strategies for Cardiovascular Diseases. Antioxidants. 2021; 10(12):1939. DOI:10.3390/antiox10121939. IF:7,675.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Sanchez L, Fite J, Peypoch O, Moreno J, Jubert Q, Carricas BS, Dilme JF, Escudero JR. Preoperative geriatric assessment, a promising tool to improve outcomes in aortic pathology interventions. INTERNATIONAL ANGIOLOGY. 2021; 40(4). DOI:10.23736/S0392-9590.21.04643-5. PMID:33913311. IF:2,103.
Small AM, Huffman JE, Klarin D, Sabater M, Lynch JA, Assimes TL, Sun YV, Miller D, Freiberg MS, Morrison AC, Rader DJ, Wilson PWF, Cho K, Tsao PS, Chang KM, Smith NL, O’Donnell CJ, de Vries PS, Damrauer SM, Cohorts Heart Aging Res Genomic &, VA Million Veteran P. Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021; 41(1). DOI:10.1161/ATVBAHA.119.313847. PMID:32847391. IF:10,514.
Thibord F, Song C, Pattee J, Rodriguez B, Chen MH, O’Donnell CJ, Kleber ME, Delgado GE, Guo XQ, Yao J, Taylor KD, Ozel AB, Brody JA, McKnight B, Gyorgy B, Simonsick E, Leonard HL, Carrasquilla GD, Guindo M, Silveira A, Temprano G, Yanek LR, Becker DM, Mathias RA, Becker LC, Raffield LM, Kilpelainen TO, Grarup N, Pedersen O, Hansen T, et al. [Sabater M]. FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2021; 19(8). DOI:10.1111/jth.15345. PMID:33876560. IF:16,036.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

MALALTIES CARDIOVASCULARS

Genòmica de Malalties Complexes

Resum

Línies de Recerca

Reptes científics

Col·laboracions

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Memoria IIB-Sant-Pau-2020- Genómica

Publicacions rellevants del últims 5 anys

Resum

Línies de Recerca

Reptes científics

Col·laboracions

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Institut de recerca de l’hospital de la santa creu i sant pau