Sant Pau - Institut de Recerca

Principals línies de recerca

Neuroreparació després de l’ictus isquèmic.
Rol de l’estatina en ictus isquèmic i hemorràgic.
Prevenció de l’hemorràgia cerebral amb anticoagulants.
Cèl·lules progenitores endotelials en ictus.
Classificació etiològica de l’hemorràgia cerebral.
Patofisiologia del creixement de l’hematoma en hemorràgia cerebral aguda.
Beneficis i riscs de la trombòlisi intravenosa.
Sonotrombòlisi.
Monitoratge no invasiu del flux cerebral amb mètodes òptics aplicats.
Participació en assajos clínics.

Reptes

Millorar la cooperació amb altres grups en el marc de la recerca espanyola en ictus.
Xarxa RETICS/INVICTUS i cooperació intrahospitalària (Institut Català de Ciències Cardiovasculars i el grup de Trombosis i Hemostàsia), i cooperació extrahospitalària (amb grups dirigits pel Dr. García Verdugo a València, Dr. Arús a la Universitat Autònoma de Barcelona Dra. Anna Planas a l’Hospital Clínic de Barcelona, Dr. Turgut Durduran a l’ICFO). Obtenció de finançament FIS, autoritats regionals i companyies privades.
Incrementar el número d’investigadors contractats i subvencionats i desenvolupar professionalment els investigadors ja existents.

Coordinació del grup

MARTI FABREGAS, JOAN FGS
jmarti@santpau.cat

Membres

Aguilera Simon, Ana IR

Camps Renom, Pol FGS

Gallego Fabrega, Cristina IR

Izquierdo Tapiz, Artur IR

Marin Bueno, Rebeca IR

Martinez Domeño, Alejandro FGS

Prats Sanchez, Luis Antonio FGS

Puig Grifol, Nuria IR

Ramos Pachon, Anna FGS

Publicacions 2021

Arranz MJ, Gallego C, Martin A, Soler J, Elices M, Dominguez E, Salazar J, Vega D, Briones L, Pascual JC. A genome-wide methylation study reveals X chromosome and childhood trauma methylation alterations associated with borderline personality disorder. Translational Psychiatry. 2021; 11(1):5. DOI:10.1038/s41398-020-01139-z. PMID:33414392. IF:7,989.
Best JG, Ambler G, Wilson D, Lee KJ, Lim JS, Shiozawa M, Koga M, Li LX, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats L, Martinez A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Ben E, Hallevi H, et al. [Gomez B, Marti J]. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. LANCET NEUROLOGY. 2021; 20(4). PMID:33743239. IF:59,935.
Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF: 4,757
Camps P, Jimenez E, Soler M, Puig N, Aguilera A, Marin R, Prats L, Delgado R, Martinez A, Guisado D, Guasch M, Marti J. Endothelial Progenitor Cells Count after Acute Ischemic Stroke Predicts Functional Outcome in Patients with Carotid Atherosclerosis. Journal of Stroke & Cerebrovascular Diseases. 2021; 30(12): 106144. DOI:10.1016/j.jstrokecerebrovasdis.2021.106144. PMID:34649037. IF: 2,677
Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF: 4,757
Carcel J, Cullell N, Muino E, Gallego C, Lledos M, Ibanez L, Krupinski J, Montaner J, Cruchaga C, Lee JM, Gill D, Pare G, Mola M, Roquer J, Jimenez J, Marti J, Fernandez I. Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke A Mendelian Randomization Study. STROKE. 2021; 52(7). DOI:10.1161/STROKEAHA.120.033041. PMID:33902302. IF: 10,170
Carrera C, Carcel J, Cullell N, Torres N, Muino E, Castillo J, Sobrino T, Campos F, Rodriguez E, Llucia L, Millan M, Munoz L, Lopez E, Bustamante A, Ribo M, Alvarez J, Jimenez J, Roquer J, Giralt E, Soriano C, Mola M, Vives C, Navarro RD, Tur S, Obach V, Arenillas JF, Segura T, Serrano G, Marti J, Delgado R, Freijo MM, Moniche F, et al. [Gallego C, Fernandez I]. Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma. BRAIN. 2021; 144. DOI:10.1093/brain/awab090. PMID:33723576. IF: 15,255
Cole JW, Adigun T, Akinyemi R, Akpa OM, Bell S, Chen BW, Conde JJ, Dobao UL, Fernandez I, Fornage M, Gallego C, Jern C, Krawczak M, Lindgren A, Markus HS, Melander O, Owolabi M, Schlicht K, Soderholm M, Srinivasasainagendra V, Tarraga CS, Stenman M, Tiwari H, Corasaniti M, Fecteau N, Guizzardi B, Lopez H, Nguyen K, Gaynor B, O’Connor T, et al. The copy number variation and stroke (CaNVAS) risk and outcome study. PLoS One. 2021; 16(4):e0248791. DOI:10.1371/journal.pone.0248791. PMID:33872305. IF: 3,752
Cullell N, Carcel J, Gallego C, Muino E, Llucia L, Lledos M, Amaut K, Krupinski J, Fernandez I. Sleep/wake cycle alterations as a cause of neurodegenerative diseases: a mendelian randomization study. NEUROBIOLOGY OF AGING. 2021; 106. DOI:10.1016/j.neurobiolaging.2021.05.008. PMID:34130902. IF: 5,133
Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF: 4,964
Gomez A, Lazcano U, Vivanco RM, Prats L, Guisado D, Delgado R, Camps P, Domeno AM, Cuadrado E, Steinhauer EG, Jimenez J, Soriano C, Avellaneda C, Rodriguez A, Marti J, Ois A, Roquer J. Defining Minor Intracerebral Hemorrhage. CEREBROVASCULAR DISEASES. 2021; 50(4). DOI:10.1159/000515169. PMID:33831860. IF: 3,104
Gregori C, Mesquita RC, Favilla CG, Busch DR, Blanco I, Zirak P, Frisk LK, Avtzi S, Maruccia F, Giacalone G, Cotta G, Camps P, Mullen MT, Marti J, Prats L, Martinez A, Kasner SE, Greenberg JH, Zhou C, Edlow BL, Putt ME, Detre JA, Yodh AG, Durduran T, Delgado R. Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease. BMC Neurology. 2021; 21(1):154. DOI:10.1186/s12883-021-02179-8. PMID:33836684. IF: 2,903
Guasch M, Prats L, Martinez A, Delgado R, Camps P, Guisado D, Abilleira S, Marti J. Patterns of Admission and Outcomes for Patients with Intracranial Hemorrhage in Catalonia, Spain. World Neurosurgery. 2021; 149. DOI:10.1016/j.wneu.2020.12.129. PMID:33412328. IF: 2,210
Guisado-Alonso D, Edo MC, Estrada Alarcón PV, García-Sánchez SM, Font MÀ, Mena Romo L, Marrero-González P, Mengual JJ, Castrillo L, Montull C, Corominas H, Gómez-Choco M. Progression of Large Vessel Disease in Patients With Giant Cell Arteritis-Associated Ischemic Stroke: The Role of Vascular Imaging: A Case Series. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2021;27(8):e418-e424. DOI:10.1097/RHU.0000000000001498. PMID: 32732523. IF: 3,902
Guisado D, Martinez A, Prats L, Delgado R, Camps P, Abilleira S, De la Ossa NP, Ramos A, Cardona P, Rodriguez A, Molina CA, Rudilosso S, Marti J. Reasons for Not Performing Mechanical Thrombectomy A Population-Based Study of Stroke Codes. STROKE. 2021; 52(9). DOI:10.1161/STROKEAHA.120.032648. PMID:34289711. IF: 10,170
Heitsch L, Ibanez L, Carrera C, Binkley MM, Strbian D, Tatlisumak T, Bustamante A, Ribo M, Molina C, Davalos A, Lopez E, Munoz L, Soriano C, Giralt E, Obach V, Slowik A, Pera J, Lapicka K, Derbisz J, Sobrino T, Castillo J, Campos F, Rodriguez E, Arias S, Segura T, Serrano G, Vives C, Diaz R, Tur S, Jimenez C, Marti J, Delgado R, et al. [Cullell N, Muino E, Carcel J, Fernandez I]. Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome. STROKE. 2021; 52(1). DOI:10.1161/STROKEAHA.119.028687. PMID:33317415. IF: 10,170
Kim NY, Hsu J, Talmasov D, Joutsa J, Soussand L, Wu O, Rost NS, Morenas E, Marti J, Pascual A, Corlett PR, Fox MD. Lesions causing hallucinations localize to one common brain network. MOLECULAR PSYCHIATRY. 2021; 26(4). DOI:10.1038/s41380-019-0565-3. PMID:31659272. IF: 13,437
Llucia L, Muino E, Gallego C, Carcel J, Martin J, Lledos M, Cullell N, Fernandez I. Pharmacogenetics studies in stroke patients treated with rtPA: a review of the most interesting findings. PHARMACOGENOMICS. 2021; 22(16). DOI:10.2217/pgs-2021-0100. PMID:34698533. IF: 2,638
Marti J, Guisado D, Delgado R, Martinez A, Prats L, Guasch M, Cardona P, Nunez A, Requena M, Rubiera M, Olive M, Bustamante A, Gomis M, Amaro S, Llull L, Ustrell X, de Oliveira GC, Sero L, Gomez M, Mena L, Serena J, Viturro SB, Purroy F, Vicente M, Rodriguez A, Ois A, Catena E, Garcia MC, Barrachina O, Palomeras E, Krupinski J, et al. [Camps P]. Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke. STROKE. 2021; 52(12). DOI:10.1161/STROKEAHA.121.034883. PMID:34455823. IF: 10,170
Martin L, Camps P, Lleixa C, Pascual E, Diaz J, Rojas R, De Luna N, Gallardo E, Cortes E, Munoz L, Alcolea D, Lleo A, Casasnovas C, Homedes C, Gutierrez G, Jimeno MC, Berciano J, Sedano MJ, Garcia T, Pardo J, Marquez C, Rojas I, Jerico I, Martinez E, de la Tassa GM, Dominguez C, Illa I, Querol L. Serum neurofilament light chain predicts long-term prognosis in Guillain-Barre syndrome patients. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2021; 92(1). DOI:10.1136/jnnp-2020-323899. PMID:33154183. IF: 13,654
McCabe JJ, Camps P, Giannotti N, McNulty JP, Coveney S, Murphy S, Barry M, Harbison J, Cronin S, Williams D, Horgan G, Dolan E, Cassidy T, McDonnell C, Kavanagh E, Foley S, Collins S, O’Connell M, Fernandez A, Delgado R, Marnane M, Marti J, Kelly PJ. Carotid Plaque Inflammation Imaged by PET and Prediction of Recurrent Stroke at 5 Years. NEUROLOGY. 2021; 97(23). DOI:10.1212/WNL.0000000000012909. PMID:34610991. IF: 11,800
Millán M, Ramos A, Dorado L, Bustamante A, Hernández M, Rodríguez L, Gomis M, Remollo S, Castaño C, Werner M, Wenger D, Rubio S, Domínguez M, Terceño M, Paipa AJ, Rodríguez A, Boned S, Camps P, Cánovas D, Giralt E, López E, Dávalos A, Ros J, Pérez de la Ossa N. Predictors of Functional Outcome After Thrombectomy in Patients With Prestroke Disability in Clinical Practice. STROKE. 2022; 53(3). DOI:10.1161/STROKEAHA.121.034960. PMID:34702065. IF: 10,170
Muino E, Carcel J, Carrera C, Llucia L, Gallego C, Cullell N, Lledos M, Castillo J, Sobrino T, Campos F, Rodriguez E, Millan M, Munoz L, Bustamante A, Lopez E, Ribo M, Alvarez J, Jimenez J, Roquer J, Giralt E, Soriano C, Vives C, Navarro RD, Tur S, Obach V, Arenillas JF, Segura T, Serrano G, Marti J, Delgado R, Camps P, Prats L, Guisado D, et al., Int Stroke Genetic C, Spanish Stroke Genetic C [Guasch M, Marin R, Martinez A, Fernandez I]. RP11-362K2.2:RP11-767I20.1 Genetic Variation Is Associated with Post-Reperfusion Therapy Parenchymal Hematoma. A GWAS Meta-Analysis. Journal of Clinical Medicine. 2021; 10(14):3137. DOI:10.3390/jcm10143137. PMID:34300314. IF: 4,964
Muino E, Maisterra O, Jimenez J, Cullell N, Carrera C, Torres NP, Carcel J, Gallego C, Lledos M, Gonzalez J, Olmos F, Espejo E, March A, Pujol R, Rodriguez A, Romeral G, Krupinski J, Marti J, Montaner J, Roquer J, Fernandez I. Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment. Scientific Reports. 2021; 11(1):6846. DOI:10.1038/s41598-021-86349-1. PMID:33767277. IF: 4,996
Nogueira RG, Abdalkader M, Qureshi MM, Frankel MR, Mansour OY, Yamagami H, Qiu Z, Farhoudi M, Siegler JE, Yaghi S, Raz E, Sakai N, Ohara N, Piotin M, Mechtouff L, Eker O, Chalumeau V, Kleinig TJ, Pop R, Liu J, Winters HS, Shang X, Vasquez AR, Blasco J, Arenillas JF, Martinez-Galdamez M, Brehm A, Psychogios MN, Lylyk P, et al. [Ramos-Pachón A]. Global impact of COVID-19 on stroke care. International Journal of Stroke. 2021;16(5):573-584. DOI:10.1177/1747493021991652. PMID: 33459583. IF: 6,948
Pérez C, López A, Gómez C, Aguirre C, de Felipe A, de la Riva P, Calleja S, Arjona A, Serrano M, Navarro MP, Delgado R, Bashir S, Llul L, Egido J, García S, Díez N, Benavente L, de la Torre JD, Tejada H, Vesperinas A, Sánchez L, Trillo S. Management of cerebral venous thrombosis in Spain: MOTIVATE descriptive study. NEUROLOGIA. 2021. DOI:10.1016/j.nrl.2021.05.016. IF: 5,486
Ramos-Araque ME, Siegler JE, Ribo M, Requena M, López C, de Lera M, Arenillas JF, Pérez IH, Gómez-Vicente B, Talavera B, Portela PC, Guillen AN, Urra X, Llull L, Renú A, Nguyen TN, Jillella D, Nahab F, Nogueira R, Haussen D, Then R, Thon JM, Esparragoza LR, Hernández-Pérez M, Bustamante A, Mansour OY, Megahed M, Hassan T, Liebeskind DS, et al.; SVIN Multinational Registry and Task Force [Ramos A]. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry. BMC Neurology. 2021;21(1):43. DOI:10.1186/s12883-021-02075-1. PMID: 33514335. IF: 2,903
Ramos-Pachón A, López-Cancio E, Bustamante A, Pérez de la Ossa N, Millán M, Hernández-Pérez M, Garcia-Berrocoso T, Cardona P, Rubiera M, Serena J, Ustrell X, Garcés M, Terceño M, Dávalos A, Montaner J. D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke. Stroke. 2021;52(3):852-858. DOI:10.1161/STROKEAHA.120.031657. PMID: 33563016. IF: 10,170
Ramos A, Garcia A, Millan M, Ribo M, Amaro S, Cardona P, Marti J, Roquer J, Silva Y, Ustrell X, Purroy F, Gomez M, Zaragoza J, Canovas D, Krupinski J, Sala NM, Palomeras E, Cocho D, Redondo L, Repullo C, Sanjurjo E, Carrion D, Lopez M, Almendros MC, Barcelo M, Monedero J, Catena E, Rybyeba M, Diaz G, Jimenez X, Sola S, Hidalgo V, Pueyo MJ, de la Ossa NP, Urra X. Bottlenecks in the Acute Stroke Care System during the COVID-19 Pandemic in Catalonia. CEREBROVASCULAR DISEASES. 2021; 50(5). DOI:10.1159/000516309. PMID:34023822. IF: 3,104
Renú A, Blasco J, Millán M, Martí-Fàbregas J, Cardona P, Oleaga L, Macho J, Molina C, Roquer J, Amaro S, Dávalos A, Zarco F, Laredo C, Tomasello A, Guimaraens L, Barranco R, Castaño C, Vivas E, Ramos A, López-Rueda A, Urra X, Muchada M, Cuadrado-Godía E, Camps-Renom P, Román LS, Ríos J, Leira EC, Jovin T, Torres F, Chamorro Á; CHOICE Investigators. The Chemical Optimization of Cerebral Embolectomy trial: Study protocol. International Journal of Stroke. 2021;16(1):110-116. DOI:10.1177/1747493019895656. PMID: 31852410. IF: 6,948
Rudilosso S, Laredo C, Amaro S, Renú A, Llull L, Obach V, Moreno J, Ribó M, Abilleira S, Cardona P, Martí-Fàbregas J, Pérez de la Ossa N, Ramos A, Roquer J, Serena J, Purroy F, Urra X, Chamorro Á. Clinical improvement within 24 hours from mechanical thrombectomy as a predictor of long-term functional outcome in a multicenter population-based cohort of patients with ischemic stroke. Journal of NeuroInterventional Surgery. 2021;13(2):119-123. DOI:10.1136/neurintsurg-2020-015934. PMID: 32461229. IF: 8,572
Rudilosso S, Rios J, Rodriguez A, Gomis M, Vera V, Gomez M, Renu A, Matos N, Llull L, Purroy F, Amaro S, Terceno M, Obach V, Serena J, Marti J, Cardona P, Molina C, Rodriguez A, Canovas D, Krupinski J, Ustrell X, Torres F, San Roman L, Salvat M, Jimenez FX, Palomeras E, Catena E, Colom C, Cocho D, Baiges J, Aragones JM, Diaz G, Costa X, Almendros MC, et al. Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry. Journal of Stroke. 2021; 23(3). DOI:10.5853/jos.2021.00962. PMID:34649384. IF: 8,632
Sánchez van Kammen M, Aguiar de Sousa D, Poli S, Cordonnier C, Heldner MR, van de Munckhof A, Krzywicka K, van Haaps T, Ciccone A, Middeldorp S, Levi MM, Kremer Hovinga JA, Silvis S, Hiltunen S, Mansour M, Arauz A, Barboza MA, Field TS, Tsivgoulis G, Nagel S, Lindgren E, Tatlisumak T, Jood K, Putaala J, Ferro JM, Arnold M, et al. [Guisado-Alonso D]. Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. JAMA Neurology. 2021;78(11):1314-1323. DOI:10.1001/jamaneurol.2021.3619. PMID: 34581763. IF: 29,907
Shoamanesh A, Hart RG, Connolly SJ, Kasner SE, Smith EE, Martí-Fàbregas J, Liu YY, Uchiyama S, Mikulik R, Veltkamp R, O’Donnell MJ, Ntaios G, Muir KW, Field TS, Santo GC, Olavarria V, Mundl H, Lutsep H, Berkowitz SD, Sharma M. Microbleeds and the Effect of Anticoagulation in Patients With Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial. JAMA Neurology. 2021;78(1):11-20. DOI:10.1001/jamaneurol.2020.3836. Erratum in: JAMA Neurology. 2021;78(1):120. PMID: 33074284. IF: 29,907
Terceño M, Silva Y, Bashir S, Vera-Monge VA, Cardona P, Molina C, Chamorro Á, de la Ossa NP, Hernández-Pérez M, Werner M, Camps-Renom P, Rodríguez-Campello A, Cánovas D, Purroy F, Serena J; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy. International Journal of Stroke. 2021;16(7):792-797. DOI:10.1177/1747493020976247. PMID: 33573525. IF: 6,948
Wang YJ, Pan YS, Li H, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Birve F, Ladenvall P, Molina CA, Johnston SC, Martí J, Pham DD. Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke An Exploratory Analysis of the THALES Randomized Clinical Trial. JAMA Neurology. 2021; 78(9). DOI:10.1001/jamaneurol.2021.2440. PMID:34244703. IF: 29,907

Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC; THALES Steering Committee and Investigators. Ticagrelor Added to Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke: A Randomized Clinical Trial. JAMA NEUROL. 2020 Nov 7;78(2):1–9. doi: 10.1001/jamaneurol.2020.4396. Epub ahead of print. Erratum in: doi: 10.1001/jamaneurol.2020.4906. PMID: 33159526; PMCID: PMC7648910.

IF: 18,3020

Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC; THALES Steering Committee and Investigators. Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin. Stroke. 2020 Dec;51(12):3504-3513. doi: 10.1161/STROKEAHA.120.032239. Epub 2020 Nov 16. PMID: 33198608; PMCID: PMC7678660.

IF: 7,9140

Campo-Caballero D, de la Riva P, de Arce A, Martínez-Zabaleta M, Rodríguez-Antigüedad J, Ekiza J, Iruzubieta P, Purroy F, Fuentes B, de Lera Alfonso M, Krupinski J, Mengual Chirife JJ, Palomeras E, Guisado-Alonso D, Rodríguez-Yáñez M, Ustrell X, Tejada García J, de Felipe Mimbrera A, Paré-Curell M, Tembl J, Cajaraville S, Garcés M, Serena J. Reperfusion treatment in acute ischaemic stroke due to cervical and cerebral artery dissection: results of a Spanish national multicentre study. Neurologia. 2020 Dec 21:S0213-4853(20)30430-8. English, Spanish. doi: 10.1016/j.nrl.2020.10.016. Epub ahead of print. PMID: 33358059.

IF: 3,1090

Camps-Renom P., Prats-Sanchez L., Casoni F., Gonzalez-de-Echavarri J.M., Marrero-Gonzalez P., Castrillon I., Marin R., Jimenez-Xarrie E., Delgado-Mederos R., Martinez-Domeno A., Guisado-Alonso D., Marti-Fabregas J. (2020) Plaque neovascularization detected with contrast-enhanced ultrasound predicts ischaemic stroke recurrence in patients with carotid atherosclerosis. EUR J NEUROL, 27 (5), 809-816.

IF: 6,0890

Colàs-Campàs L, Farre J, Mauri-Capdevila G, Molina-Seguín J, Aymerich N, Ois Á, Roquer J, Tur S, García-Carreira MDC, Martí-Fàbregas J, Cruz-Culebras A, Segura T, Arque G, Purroy F. Inflammatory Response of Ischemic Tolerance in Circulating Plasma: Preconditioning-Induced by Transient Ischemic Attack (TIA) Phenomena in Acute Ischemia Patients (AIS). Front Neurol. 2020 Oct 29;11:552470. doi: 10.3389/fneur.2020.552470. PMID: 33192985; PMCID: PMC7658473.

IF: 4,0030

Cullell N., Carrera C., Muino E., Torres-Aguila N.-P., Carcel-Marquez J., Gonzalez-Sanchez J., Gallego-Fabrega C., Molina J., Besora S., Sotoca J., Buongiorno M.-T., Jimenez-Conde J., Giralt-Steinhauer E., de Torres-Chacon R., Montaner J., Mancha F., Cabezas J.A., Marti-Fabregas J., Prats-Sanchez L., Camps-Renom P., Purroy F., Cambray S., Freijo M.D.M., Vives-Bauza C., Tur S., Font M., Lopez-Cancio E., Hernandez-Perez M., Obach V., Calleja A., Arenillas J., Rodriguez-Yanez M., Castillo J., Sobrino T., Fernandez-Cadenas I., Krupinski J. (2020) Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain. SCI REP-UK, 10 (1), 2806-.

IF: 4,3790

Fuentes B, Pastor-Yborra S, Gutiérrez-Zúñiga R, González-Pérez de Villar N, de Celis E, Rodríguez-Pardo J, Gómez-de Frutos MC, Laso-García F, Gutiérrez-Fernández M, Ortega-Casarrubios M, Soto A, López-Fernández M, Santamaría M, Díez-González N, Freijo MM, Zandio B, Delgado-Mederos R, Calleja A, Portilla-Cuenca JC, Lisbona A, Otero-Ortega L, Díez-Tejedor E. Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study. J Transl Med. 2020 Nov 4;18(1):414. doi: 10.1186/s12967-020-02586-4. PMID: 33148277; PMCID: PMC7610240.

IF: 5,5310

Garcia-Pastor A., Gil-Nunez A., Ramirez-Moreno J.M., Gonzalez-Nafria N., Tejada J., Moniche F., Portilla-Cuenca J.C., Martinez-Sanchez P., Fuentes B., Gamero-Garcia M.A., Alonso De Lecinana M., Masjuan J., Canovas D., Aladro Y., Parkhutik V., Lago A., De Arce A.M., Usero-Ruiz M., Delgado-Mederos R., Pampliega A., Ximenez-Carrillo A., Bartulos-Iglesias M., Castro-Reyes E. (2020) Progression of carotid near-occlusion to complete occlusion: Related factors and clinical implications. J NEUROINTERV SURG, 12 (12), 1180-1185.

IF: 5,8360

Gomis M., Davalos A., Purroy F., Cardona P., Rodriguez-Campello A., Marti-Fabregas J., Pagola J., Pardo L., Munoz-Narbona L., Benabdelhak I., Lara-Rodriguez B., Cuadrado-Godia E., Martinez-Domeno A., Juega J.M., Serena J., Alvarez-Ballano J., Paipa A., Roquer J., Abilleira S., Neeter R., van de Groep A., Molina C. (2020) Stroke Risk Analysis, a System With a High Detection Rate of Atrial Fibrillation in Stroke and Transient Ischemic Attack. STROKE, 51 (1), 262-267.

IF: 7,9140

Guisado-Alonso D, Edo MC, Estrada Alarcón PV, García-Sánchez SM, Font MÀ, Mena Romo L, Marrero-González P, Mengual JJ, Castrillo L, Montull C, Corominas H, Gómez-Choco M. Progression of Large Vessel Disease in Patients With Giant Cell Arteritis-Associated Ischemic Stroke: The Role of Vascular Imaging: A Case Series. J Clin Rheumatol. 2020 Jul 23. doi: 10.1097/RHU.0000000000001498. Epub ahead of print. PMID: 32732523.

IF: 3,5170

Gutierrez-Zuniga R., Alonso de Lecinana M., Delgado-Mederos R., Gallego-Cullere J., Rodriguez-Yanez M., Martinez-Zabaleta M., Freijo M., Portilla J.C., Gil-Nunez A., Diez Sebastian J., Lisbona A., Diez-Tejedor E., Fuentes B. (2020) Beyond hyperglycemia: glycaemic variability as a prognostic factor after acute ischemic stroke Más allá de la hiperglucemia: la variabilidad glucémica como factor pronóstico en el infarto cerebral agudo. NEUROLOGIA, (), -.

IF: 3,1090

Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants; Second HEADS Roundtable Participants. Recommendations for Clinical Trials in ICH: The Second Hemorrhagic Stroke Academia Industry Roundtable. Stroke. 2020 Apr;51(4):1333-1338. doi: 10.1161/STROKEAHA.119.027882. Epub 2020 Feb 10. PMID: 32078490; PMCID: PMC7093252.

IF: 7,9140

Jimenez-Xarrie E., Perez B., Dantas A.P., Puertas-Umbert L., Marti-Fabregas J., Chamorro A., Planas A.M., Vila E., Jimenez-Altayo F. (2020) Uric Acid Treatment After Stroke Prevents Long-Term Middle Cerebral Artery Remodelling and Attenuates Brain Damage in Spontaneously Hypertensive Rats. TRANSL STROKE RES, 11 (6), 1332-1347.

IF: 6,8290

Johnston SC, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y; THALES Investigators. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. New Engl J Med. 2020 Jul 16;383(3):207-217. doi: 10.1056/NEJMoa1916870. PMID: 32668111.

IF: 91,2450

Kelly P.J., Camps-Renom P., Giannotti N., Marti-Fabregas J., McNulty J.P., Baron J.-C., Barry M., Coutts S.B., Cronin S., Delgado-Mederos R., Dolan E., Fernandez-Leon A., Foley S., Harbison J., Horgan G., Kavanagh E., Marnane M., McCabe J., McDonnell C., Sharma V.K., Williams D.J., O'Connell M., Murphy S. (2020) A risk score including carotid plaque inflammation and stenosis severity improves identification of recurrent stroke. STROKE, (), 838-845.

IF: 7,9140

Martí-Carvajal AJ, Valli C, Martí-Amarista CE, Solà I, Martí-Fàbregas J, Bonfill Cosp X. Citicoline for treating people with acute ischemic stroke. Cochrane Database Syst Rev. 2020 Aug 29;8:CD013066. doi: 10.1002/14651858.CD013066.pub2. PMID: 32860632.

IF: 9,2660

Marti-Fabregas J., Delgado-Mederos R., Martinez-Domeno A., Camps-Renom P., Guisado-Alonso D., Guasch-Jimenez M., Marrero-Gonzalez P., Jimenez-Xarrie E., Marin R., Prats-Sanchez L. (2020) Clinical and radiological characteristics and outcome of wake-up intracerebral hemorrhage. SCI REP-UK, 10 (1), -.

IF: 4,3790

Martín-Aguilar L, Camps-Renom P, Lleixà C, Pascual-Goñi E, Díaz-Manera J, Rojas-García R, De Luna N, Gallardo E, Cortés-Vicente E, Muñoz L, Alcolea D, Lleó A, Casasnovas C, Homedes C, Gutiérrez-Gutiérrez G, Jimeno-Montero MC, Berciano J, Sedano-Tous MJ, García-Sobrino T, Pardo-Fernández J, Márquez-Infante C, Rojas-Marcos I, Jericó-Pascual I, Martínez-Hernández E, Morís de la Tassa G, Domínguez-González C, Illa I, Querol L. Serum neurofilament light chain predicts long-term prognosis in Guillain-Barré syndrome patients. J NEUROL NEUROSUR PS. 2020 Nov 5:jnnp-2020-323899. doi: 10.1136/jnnp-2020-323899. Epub ahead of print. PMID: 33154183.

IF: 10,1540

Martinez-Majander N., Ntaios G., Liu Y.Y., Ylikotila P., Joensuu H., Saarinen J., Perera K.S., Marti-Fabregas J., Chamorro A., Rudilosso S., Prats-Sanchez L., Berkowitz S.D., Mundl H., Themeles E., Tiainen M., Demchuk A., Kasner S.E., Hart R.G., Tatlisumak T. (2020) Rivaroxaban versus aspirin for secondary prevention of ischaemic stroke in patients with cancer: a subgroup analysis of the NAVIGATE ESUS randomized trial. EUR J NEUROL, 27 (5), 841-848.

IF: 6,0890

Mikulik R., Eckstein J., Pearce L.A., Mundl H., Rudilosso S., Olavarria V.V., Shoamanesh A., Chamorro A., Marti-Fabregas J., Veltkamp R., Ozturk S., Tatlisumak T., Tatlisumak T., Peacock W.F., Berkowitz S.D., Connolly S.J., Hart R.G. (2020) Frequency and Predictors of Major Bleeding in Patients with Embolic Strokes of Undetermined Source: NAVIGATE-ESUS Trial. STROKE, (), 2139-2147.

IF: 7,9140

Palacios-Mendoza M.A., Pastor A.G., Gil-Nunez A., Ramirez-Moreno J.M., Gonzalez-Nafria N., Moniche F., Portilla-Cuenca J.C., Fuentes B., Gamero-Garcia M.A., de Lecinana M.A., Masjuan J., Verge D.C., Aladro Y., Lago A., de Arce-Borda A.M., Usero-Ruiz M., Delgado-Mederos R., Pampliega A., Ximenez-Carrillo A., Bartulos-Iglesias M., Castro-Reyes E., Ultrasonographic and hemodynamic characteristics of patients with symptomatic carotid near-occlusion: results from a multicenter registry study (2020) NEURORADIOLOGY.

IF: 2,8040

Pascual-Goñi E, Fortea J, Martínez-Domeño A, Rabella N, Tecame M, Gómez-Oliva C, Querol L, Gómez-Ansón B. COVID-19-associated ophthalmoparesis and hypothalamic involvement. NEUROL-NEUROIMMUNOL. 2020 Jun 25;7(5):e823. doi: 10.1212/NXI.0000000000000823. PMID: 32587102; PMCID: PMC7357415.

IF: 8,4850

Puig N, Jiménez-Xarrié E, Camps-Renom P, Benitez S. Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability. INT J MOL SCI. 2020 Nov 3;21(21):8236. doi: 10.3390/ijms21218236. PMID: 33153204; PMCID: PMC7662861.

IF: 5,9230

Puig N, Montolio L, Camps-Renom P, Navarra L, Jiménez-Altayó F, Jiménez-Xarrié E, Sánchez-Quesada JL, Benitez S. Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages. CELLS-BASEL. 2020 Mar 1;9(3):583. doi: 10.3390/cells9030583. PMID: 32121518; PMCID: PMC7140452.

IF: 6,6000

Purroy F, Arque G, Mauri G, García-Vázquez C, Vicente-Pascual M, Pereira C, Vazquez-Justes D, Torres-Querol C, Vena A, Abilleira S, Cardona P, Forné C, Jiménez-Fàbrega X, Pagola J, Portero-Otin M, Rodríguez-Campello A, Rovira À, Martí-Fàbregas J. REMOTE Ischemic Perconditioning Among Acute Ischemic Stroke Patients in Catalonia: REMOTE-CAT PROJECT. FRONT NEUROL. 2020 Sep 25;11:569696. doi: 10.3389/fneur.2020.569696. PMID: 33101178; PMCID: PMC7546310.

IF: 4,0030

Sanabria-Sanchinel AA, Pérez-Almengor ES, Guasch-Jiménez M, Principe A, Ley M, Rocamora-Zúñiga RA. Epileptic aura continua: A case report with response to brivaracetam. Neurologia. 2020 Nov 4:S0213-4853(20)30304-2. English, Spanish. doi: 10.1016/j.nrl.2020.10.001. Epub ahead of print. PMID: 33160726.

IF: 3,1090

Selim M., Hanley D., Steiner T., Christensen H.K., Lafuente J., Rodriguez D., Keep R., Anderson C., Parry-Jones A., Nilsson M., Sunnerhagen K.S., Novick E., Aronowski J., Lawson B., Chaudhary N., Zhou-Ping T., Zuccarello M., Woo D., Shoamanesh A., Qureshi A.I., Cordonnier C., Anderson C., Klijn K., Salman R.A.-S., Sprigg N., Gregson B., Mendelow D., Gaudin C., Pandey A., Ziai W., Alcazar-Romero P.P., Montaner J., Marti-Fabregas J., Nilsson S., Schenk B., Riess H., You C., Gaist D., Broderick J. (2020) Recommendations for Clinical Trials in ICH: The Second Hemorrhagic Stroke Academia Industry Roundtable. STROKE, (), 1333-1338.

IF: 7,9140

Shoamanesh A, Hart RG, Connolly SJ, Kasner SE, Smith EE, Martí-Fàbregas J, Liu YY, Uchiyama S, Mikulik R, Veltkamp R, O’Donnell MJ, Ntaios G, Muir KW, Field TS, Santo GC, Olavarria V, Mundl H, Lutsep H, Berkowitz SD, Sharma M. Microbleeds and the Effect of Anticoagulation in Patients With Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial. JAMA Neurol. 2021 Jan 1;78(1):11-20. doi: 10.1001/jamaneurol.2020.3836. Erratum in: doi: 10.1001/jamaneurol.2020.4698. PMID: 33074284; PMCID: PMC7573796.

IF: 18,3020

Sobrino T, Rodríguez-Yáñez M, Campos F, Iglesias-Rey R, Millán M, de la Ossa NP, Dávalos A, Delgado-Mederos R, Martínez-Domeño A, Martí-Fábregas J, Castellanos M, Serena J, Lago A, Díez-Tejedor E, Castillo J. Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke: a Multicenter Study. Transl Stroke Res. 2020 Aug;11(4):653-663. doi: 10.1007/s12975-019-00747-2. Epub 2019 Nov 25. PMID: 31768951; PMCID: PMC7340658.

IF: 6,8290

Terceño M, Silva Y, Bashir S, Vera-Monge VA, Cardona P, Molina C, Chamorro Á, de la Ossa NP, Hernández-Pérez M, Werner M, Camps-Renom P, Rodríguez-Campello A, Cánovas D, Purroy F, Serena J; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy. Int J Stroke. 2020 Dec 1:1747493020976247. doi: 10.1177/1747493020976247. Epub ahead of print. PMID: 33573525.

IF: 5,2660

Vidal X, Martí-Fàbregas J, Canet O, Roqué M, Morral A, Tur M, Schmitz C, Sitjà-Rabert M. Efficacy of radial extracorporeal shock wave therapy compared with botulinum toxin type A injection in treatment of lower extremity spasticity in subjects with cerebral palsy: A randomized, controlled, cross-over study. J Rehabil Med. 2020 Jun 30;52(6):jrm00076. doi: 10.2340/16501977-2703. PMID: 32556354.

IF: 2,9120

2017 Scientific Report – Cerebrovascular Diseases

presentació

Principals línies de recerca

Neuroreparació després de l’ictus isquèmic.
Rol de l’estatina en ictus isquèmic i hemorràgic.
Prevenció de l’hemorràgia cerebral amb anticoagulants.
Cèl·lules progenitores endotelials en ictus.
Classificació etiològica de l’hemorràgia cerebral.
Patofisiologia del creixement de l’hematoma en hemorràgia cerebral aguda.
Beneficis i riscs de la trombòlisi intravenosa.
Sonotrombòlisi.
Monitoratge no invasiu del flux cerebral amb mètodes òptics aplicats.
Participació en assajos clínics.

Reptes

Millorar la cooperació amb altres grups en el marc de la recerca espanyola en ictus.
Xarxa RETICS/INVICTUS i cooperació intrahospitalària (Institut Català de Ciències Cardiovasculars i el grup de Trombosis i Hemostàsia), i cooperació extrahospitalària (amb grups dirigits pel Dr. García Verdugo a València, Dr. Arús a la Universitat Autònoma de Barcelona Dra. Anna Planas a l’Hospital Clínic de Barcelona, Dr. Turgut Durduran a l’ICFO). Obtenció de finançament FIS, autoritats regionals i companyies privades.
Incrementar el número d’investigadors contractats i subvencionats i desenvolupar professionalment els investigadors ja existents.

equip

Coordinació del grup

MARTI FABREGAS, JOAN FGS
jmarti@santpau.cat

Membres

Aguilera Simon, Ana IR

Camps Renom, Pol FGS

Gallego Fabrega, Cristina IR

Izquierdo Tapiz, Artur IR

Marin Bueno, Rebeca IR

Martinez Domeño, Alejandro FGS

Prats Sanchez, Luis Antonio FGS

Puig Grifol, Nuria IR

Ramos Pachon, Anna FGS

producció científica

Publicacions 2021

Arranz MJ, Gallego C, Martin A, Soler J, Elices M, Dominguez E, Salazar J, Vega D, Briones L, Pascual JC. A genome-wide methylation study reveals X chromosome and childhood trauma methylation alterations associated with borderline personality disorder. Translational Psychiatry. 2021; 11(1):5. DOI:10.1038/s41398-020-01139-z. PMID:33414392. IF:7,989.
Best JG, Ambler G, Wilson D, Lee KJ, Lim JS, Shiozawa M, Koga M, Li LX, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats L, Martinez A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Ben E, Hallevi H, et al. [Gomez B, Marti J]. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. LANCET NEUROLOGY. 2021; 20(4). PMID:33743239. IF:59,935.
Bonaterra A, Fernandez S, Rivas A, Puig N, Benitez S, Pancorbo O, Rodriguez D, Pujadas F, Freijo MD, Tur S, Martinez M, Portela PC, Vera R, Lebrato L, Arenillas JF, Perez S, Montaner J, Sanchez JL, Hernandez M. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines. 2021; 9(1):72. DOI:10.3390/biomedicines9010072. PMID:33445800. IF: 4,757
Camps P, Jimenez E, Soler M, Puig N, Aguilera A, Marin R, Prats L, Delgado R, Martinez A, Guisado D, Guasch M, Marti J. Endothelial Progenitor Cells Count after Acute Ischemic Stroke Predicts Functional Outcome in Patients with Carotid Atherosclerosis. Journal of Stroke & Cerebrovascular Diseases. 2021; 30(12): 106144. DOI:10.1016/j.jstrokecerebrovasdis.2021.106144. PMID:34649037. IF: 2,677
Canyelles M, Garcia A, Junza A, Yanes O, Puig N, Ordonez J, Sionis A, Sans J, Alquezar A, Santos D, Rotllan N, Julve J, Tondo M, Escola JC, Blanco F. The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux-But Not Gut Microbial-Derived Metabolites-Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction. Biomedicines. 2021; 9(10):1336. DOI:10.3390/biomedicines9101336. PMID:34680453. IF: 4,757
Carcel J, Cullell N, Muino E, Gallego C, Lledos M, Ibanez L, Krupinski J, Montaner J, Cruchaga C, Lee JM, Gill D, Pare G, Mola M, Roquer J, Jimenez J, Marti J, Fernandez I. Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke A Mendelian Randomization Study. STROKE. 2021; 52(7). DOI:10.1161/STROKEAHA.120.033041. PMID:33902302. IF: 10,170
Carrera C, Carcel J, Cullell N, Torres N, Muino E, Castillo J, Sobrino T, Campos F, Rodriguez E, Llucia L, Millan M, Munoz L, Lopez E, Bustamante A, Ribo M, Alvarez J, Jimenez J, Roquer J, Giralt E, Soriano C, Mola M, Vives C, Navarro RD, Tur S, Obach V, Arenillas JF, Segura T, Serrano G, Marti J, Delgado R, Freijo MM, Moniche F, et al. [Gallego C, Fernandez I]. Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma. BRAIN. 2021; 144. DOI:10.1093/brain/awab090. PMID:33723576. IF: 15,255
Cole JW, Adigun T, Akinyemi R, Akpa OM, Bell S, Chen BW, Conde JJ, Dobao UL, Fernandez I, Fornage M, Gallego C, Jern C, Krawczak M, Lindgren A, Markus HS, Melander O, Owolabi M, Schlicht K, Soderholm M, Srinivasasainagendra V, Tarraga CS, Stenman M, Tiwari H, Corasaniti M, Fecteau N, Guizzardi B, Lopez H, Nguyen K, Gaynor B, O’Connor T, et al. The copy number variation and stroke (CaNVAS) risk and outcome study. PLoS One. 2021; 16(4):e0248791. DOI:10.1371/journal.pone.0248791. PMID:33872305. IF: 3,752
Cullell N, Carcel J, Gallego C, Muino E, Llucia L, Lledos M, Amaut K, Krupinski J, Fernandez I. Sleep/wake cycle alterations as a cause of neurodegenerative diseases: a mendelian randomization study. NEUROBIOLOGY OF AGING. 2021; 106. DOI:10.1016/j.neurobiolaging.2021.05.008. PMID:34130902. IF: 5,133
Genua I, Puig N, Minambres I, Benitez S, Gil P, Grau M, Rivas A, Balague C, Fernandez S, Garcia A, Perez A, Sanchez JL. Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity. Journal of Clinical Medicine. 2021; 10(8):1716. DOI:10.3390/jcm10081716. PMID:33923393. IF: 4,964
Gomez A, Lazcano U, Vivanco RM, Prats L, Guisado D, Delgado R, Camps P, Domeno AM, Cuadrado E, Steinhauer EG, Jimenez J, Soriano C, Avellaneda C, Rodriguez A, Marti J, Ois A, Roquer J. Defining Minor Intracerebral Hemorrhage. CEREBROVASCULAR DISEASES. 2021; 50(4). DOI:10.1159/000515169. PMID:33831860. IF: 3,104
Gregori C, Mesquita RC, Favilla CG, Busch DR, Blanco I, Zirak P, Frisk LK, Avtzi S, Maruccia F, Giacalone G, Cotta G, Camps P, Mullen MT, Marti J, Prats L, Martinez A, Kasner SE, Greenberg JH, Zhou C, Edlow BL, Putt ME, Detre JA, Yodh AG, Durduran T, Delgado R. Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease. BMC Neurology. 2021; 21(1):154. DOI:10.1186/s12883-021-02179-8. PMID:33836684. IF: 2,903
Guasch M, Prats L, Martinez A, Delgado R, Camps P, Guisado D, Abilleira S, Marti J. Patterns of Admission and Outcomes for Patients with Intracranial Hemorrhage in Catalonia, Spain. World Neurosurgery. 2021; 149. DOI:10.1016/j.wneu.2020.12.129. PMID:33412328. IF: 2,210
Guisado-Alonso D, Edo MC, Estrada Alarcón PV, García-Sánchez SM, Font MÀ, Mena Romo L, Marrero-González P, Mengual JJ, Castrillo L, Montull C, Corominas H, Gómez-Choco M. Progression of Large Vessel Disease in Patients With Giant Cell Arteritis-Associated Ischemic Stroke: The Role of Vascular Imaging: A Case Series. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2021;27(8):e418-e424. DOI:10.1097/RHU.0000000000001498. PMID: 32732523. IF: 3,902
Guisado D, Martinez A, Prats L, Delgado R, Camps P, Abilleira S, De la Ossa NP, Ramos A, Cardona P, Rodriguez A, Molina CA, Rudilosso S, Marti J. Reasons for Not Performing Mechanical Thrombectomy A Population-Based Study of Stroke Codes. STROKE. 2021; 52(9). DOI:10.1161/STROKEAHA.120.032648. PMID:34289711. IF: 10,170
Heitsch L, Ibanez L, Carrera C, Binkley MM, Strbian D, Tatlisumak T, Bustamante A, Ribo M, Molina C, Davalos A, Lopez E, Munoz L, Soriano C, Giralt E, Obach V, Slowik A, Pera J, Lapicka K, Derbisz J, Sobrino T, Castillo J, Campos F, Rodriguez E, Arias S, Segura T, Serrano G, Vives C, Diaz R, Tur S, Jimenez C, Marti J, Delgado R, et al. [Cullell N, Muino E, Carcel J, Fernandez I]. Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome. STROKE. 2021; 52(1). DOI:10.1161/STROKEAHA.119.028687. PMID:33317415. IF: 10,170
Kim NY, Hsu J, Talmasov D, Joutsa J, Soussand L, Wu O, Rost NS, Morenas E, Marti J, Pascual A, Corlett PR, Fox MD. Lesions causing hallucinations localize to one common brain network. MOLECULAR PSYCHIATRY. 2021; 26(4). DOI:10.1038/s41380-019-0565-3. PMID:31659272. IF: 13,437
Llucia L, Muino E, Gallego C, Carcel J, Martin J, Lledos M, Cullell N, Fernandez I. Pharmacogenetics studies in stroke patients treated with rtPA: a review of the most interesting findings. PHARMACOGENOMICS. 2021; 22(16). DOI:10.2217/pgs-2021-0100. PMID:34698533. IF: 2,638
Marti J, Guisado D, Delgado R, Martinez A, Prats L, Guasch M, Cardona P, Nunez A, Requena M, Rubiera M, Olive M, Bustamante A, Gomis M, Amaro S, Llull L, Ustrell X, de Oliveira GC, Sero L, Gomez M, Mena L, Serena J, Viturro SB, Purroy F, Vicente M, Rodriguez A, Ois A, Catena E, Garcia MC, Barrachina O, Palomeras E, Krupinski J, et al. [Camps P]. Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke. STROKE. 2021; 52(12). DOI:10.1161/STROKEAHA.121.034883. PMID:34455823. IF: 10,170
Martin L, Camps P, Lleixa C, Pascual E, Diaz J, Rojas R, De Luna N, Gallardo E, Cortes E, Munoz L, Alcolea D, Lleo A, Casasnovas C, Homedes C, Gutierrez G, Jimeno MC, Berciano J, Sedano MJ, Garcia T, Pardo J, Marquez C, Rojas I, Jerico I, Martinez E, de la Tassa GM, Dominguez C, Illa I, Querol L. Serum neurofilament light chain predicts long-term prognosis in Guillain-Barre syndrome patients. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2021; 92(1). DOI:10.1136/jnnp-2020-323899. PMID:33154183. IF: 13,654
McCabe JJ, Camps P, Giannotti N, McNulty JP, Coveney S, Murphy S, Barry M, Harbison J, Cronin S, Williams D, Horgan G, Dolan E, Cassidy T, McDonnell C, Kavanagh E, Foley S, Collins S, O’Connell M, Fernandez A, Delgado R, Marnane M, Marti J, Kelly PJ. Carotid Plaque Inflammation Imaged by PET and Prediction of Recurrent Stroke at 5 Years. NEUROLOGY. 2021; 97(23). DOI:10.1212/WNL.0000000000012909. PMID:34610991. IF: 11,800
Millán M, Ramos A, Dorado L, Bustamante A, Hernández M, Rodríguez L, Gomis M, Remollo S, Castaño C, Werner M, Wenger D, Rubio S, Domínguez M, Terceño M, Paipa AJ, Rodríguez A, Boned S, Camps P, Cánovas D, Giralt E, López E, Dávalos A, Ros J, Pérez de la Ossa N. Predictors of Functional Outcome After Thrombectomy in Patients With Prestroke Disability in Clinical Practice. STROKE. 2022; 53(3). DOI:10.1161/STROKEAHA.121.034960. PMID:34702065. IF: 10,170
Muino E, Carcel J, Carrera C, Llucia L, Gallego C, Cullell N, Lledos M, Castillo J, Sobrino T, Campos F, Rodriguez E, Millan M, Munoz L, Bustamante A, Lopez E, Ribo M, Alvarez J, Jimenez J, Roquer J, Giralt E, Soriano C, Vives C, Navarro RD, Tur S, Obach V, Arenillas JF, Segura T, Serrano G, Marti J, Delgado R, Camps P, Prats L, Guisado D, et al., Int Stroke Genetic C, Spanish Stroke Genetic C [Guasch M, Marin R, Martinez A, Fernandez I]. RP11-362K2.2:RP11-767I20.1 Genetic Variation Is Associated with Post-Reperfusion Therapy Parenchymal Hematoma. A GWAS Meta-Analysis. Journal of Clinical Medicine. 2021; 10(14):3137. DOI:10.3390/jcm10143137. PMID:34300314. IF: 4,964
Muino E, Maisterra O, Jimenez J, Cullell N, Carrera C, Torres NP, Carcel J, Gallego C, Lledos M, Gonzalez J, Olmos F, Espejo E, March A, Pujol R, Rodriguez A, Romeral G, Krupinski J, Marti J, Montaner J, Roquer J, Fernandez I. Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment. Scientific Reports. 2021; 11(1):6846. DOI:10.1038/s41598-021-86349-1. PMID:33767277. IF: 4,996
Nogueira RG, Abdalkader M, Qureshi MM, Frankel MR, Mansour OY, Yamagami H, Qiu Z, Farhoudi M, Siegler JE, Yaghi S, Raz E, Sakai N, Ohara N, Piotin M, Mechtouff L, Eker O, Chalumeau V, Kleinig TJ, Pop R, Liu J, Winters HS, Shang X, Vasquez AR, Blasco J, Arenillas JF, Martinez-Galdamez M, Brehm A, Psychogios MN, Lylyk P, et al. [Ramos-Pachón A]. Global impact of COVID-19 on stroke care. International Journal of Stroke. 2021;16(5):573-584. DOI:10.1177/1747493021991652. PMID: 33459583. IF: 6,948
Pérez C, López A, Gómez C, Aguirre C, de Felipe A, de la Riva P, Calleja S, Arjona A, Serrano M, Navarro MP, Delgado R, Bashir S, Llul L, Egido J, García S, Díez N, Benavente L, de la Torre JD, Tejada H, Vesperinas A, Sánchez L, Trillo S. Management of cerebral venous thrombosis in Spain: MOTIVATE descriptive study. NEUROLOGIA. 2021. DOI:10.1016/j.nrl.2021.05.016. IF: 5,486
Ramos-Araque ME, Siegler JE, Ribo M, Requena M, López C, de Lera M, Arenillas JF, Pérez IH, Gómez-Vicente B, Talavera B, Portela PC, Guillen AN, Urra X, Llull L, Renú A, Nguyen TN, Jillella D, Nahab F, Nogueira R, Haussen D, Then R, Thon JM, Esparragoza LR, Hernández-Pérez M, Bustamante A, Mansour OY, Megahed M, Hassan T, Liebeskind DS, et al.; SVIN Multinational Registry and Task Force [Ramos A]. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry. BMC Neurology. 2021;21(1):43. DOI:10.1186/s12883-021-02075-1. PMID: 33514335. IF: 2,903
Ramos-Pachón A, López-Cancio E, Bustamante A, Pérez de la Ossa N, Millán M, Hernández-Pérez M, Garcia-Berrocoso T, Cardona P, Rubiera M, Serena J, Ustrell X, Garcés M, Terceño M, Dávalos A, Montaner J. D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke. Stroke. 2021;52(3):852-858. DOI:10.1161/STROKEAHA.120.031657. PMID: 33563016. IF: 10,170
Ramos A, Garcia A, Millan M, Ribo M, Amaro S, Cardona P, Marti J, Roquer J, Silva Y, Ustrell X, Purroy F, Gomez M, Zaragoza J, Canovas D, Krupinski J, Sala NM, Palomeras E, Cocho D, Redondo L, Repullo C, Sanjurjo E, Carrion D, Lopez M, Almendros MC, Barcelo M, Monedero J, Catena E, Rybyeba M, Diaz G, Jimenez X, Sola S, Hidalgo V, Pueyo MJ, de la Ossa NP, Urra X. Bottlenecks in the Acute Stroke Care System during the COVID-19 Pandemic in Catalonia. CEREBROVASCULAR DISEASES. 2021; 50(5). DOI:10.1159/000516309. PMID:34023822. IF: 3,104
Renú A, Blasco J, Millán M, Martí-Fàbregas J, Cardona P, Oleaga L, Macho J, Molina C, Roquer J, Amaro S, Dávalos A, Zarco F, Laredo C, Tomasello A, Guimaraens L, Barranco R, Castaño C, Vivas E, Ramos A, López-Rueda A, Urra X, Muchada M, Cuadrado-Godía E, Camps-Renom P, Román LS, Ríos J, Leira EC, Jovin T, Torres F, Chamorro Á; CHOICE Investigators. The Chemical Optimization of Cerebral Embolectomy trial: Study protocol. International Journal of Stroke. 2021;16(1):110-116. DOI:10.1177/1747493019895656. PMID: 31852410. IF: 6,948
Rudilosso S, Laredo C, Amaro S, Renú A, Llull L, Obach V, Moreno J, Ribó M, Abilleira S, Cardona P, Martí-Fàbregas J, Pérez de la Ossa N, Ramos A, Roquer J, Serena J, Purroy F, Urra X, Chamorro Á. Clinical improvement within 24 hours from mechanical thrombectomy as a predictor of long-term functional outcome in a multicenter population-based cohort of patients with ischemic stroke. Journal of NeuroInterventional Surgery. 2021;13(2):119-123. DOI:10.1136/neurintsurg-2020-015934. PMID: 32461229. IF: 8,572
Rudilosso S, Rios J, Rodriguez A, Gomis M, Vera V, Gomez M, Renu A, Matos N, Llull L, Purroy F, Amaro S, Terceno M, Obach V, Serena J, Marti J, Cardona P, Molina C, Rodriguez A, Canovas D, Krupinski J, Ustrell X, Torres F, San Roman L, Salvat M, Jimenez FX, Palomeras E, Catena E, Colom C, Cocho D, Baiges J, Aragones JM, Diaz G, Costa X, Almendros MC, et al. Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry. Journal of Stroke. 2021; 23(3). DOI:10.5853/jos.2021.00962. PMID:34649384. IF: 8,632
Sánchez van Kammen M, Aguiar de Sousa D, Poli S, Cordonnier C, Heldner MR, van de Munckhof A, Krzywicka K, van Haaps T, Ciccone A, Middeldorp S, Levi MM, Kremer Hovinga JA, Silvis S, Hiltunen S, Mansour M, Arauz A, Barboza MA, Field TS, Tsivgoulis G, Nagel S, Lindgren E, Tatlisumak T, Jood K, Putaala J, Ferro JM, Arnold M, et al. [Guisado-Alonso D]. Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. JAMA Neurology. 2021;78(11):1314-1323. DOI:10.1001/jamaneurol.2021.3619. PMID: 34581763. IF: 29,907
Shoamanesh A, Hart RG, Connolly SJ, Kasner SE, Smith EE, Martí-Fàbregas J, Liu YY, Uchiyama S, Mikulik R, Veltkamp R, O’Donnell MJ, Ntaios G, Muir KW, Field TS, Santo GC, Olavarria V, Mundl H, Lutsep H, Berkowitz SD, Sharma M. Microbleeds and the Effect of Anticoagulation in Patients With Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial. JAMA Neurology. 2021;78(1):11-20. DOI:10.1001/jamaneurol.2020.3836. Erratum in: JAMA Neurology. 2021;78(1):120. PMID: 33074284. IF: 29,907
Terceño M, Silva Y, Bashir S, Vera-Monge VA, Cardona P, Molina C, Chamorro Á, de la Ossa NP, Hernández-Pérez M, Werner M, Camps-Renom P, Rodríguez-Campello A, Cánovas D, Purroy F, Serena J; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy. International Journal of Stroke. 2021;16(7):792-797. DOI:10.1177/1747493020976247. PMID: 33573525. IF: 6,948
Wang YJ, Pan YS, Li H, Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Birve F, Ladenvall P, Molina CA, Johnston SC, Martí J, Pham DD. Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke An Exploratory Analysis of the THALES Randomized Clinical Trial. JAMA Neurology. 2021; 78(9). DOI:10.1001/jamaneurol.2021.2440. PMID:34244703. IF: 29,907

Publicacions 2020

IF: 18,3020

Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC; THALES Steering Committee and Investigators. Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin. Stroke. 2020 Dec;51(12):3504-3513. doi: 10.1161/STROKEAHA.120.032239. Epub 2020 Nov 16. PMID: 33198608; PMCID: PMC7678660.

IF: 7,9140

IF: 3,1090

IF: 6,0890

IF: 4,0030

IF: 4,3790

IF: 5,5310

IF: 5,8360

IF: 7,9140

IF: 3,5170

IF: 3,1090

IF: 7,9140

IF: 6,8290

IF: 91,2450

IF: 7,9140

IF: 9,2660

IF: 4,3790

IF: 10,1540

IF: 6,0890

IF: 7,9140

IF: 2,8040

IF: 8,4850

IF: 5,9230

IF: 6,6000

IF: 4,0030

IF: 3,1090

IF: 7,9140

IF: 18,3020

IF: 6,8290

IF: 5,2660

IF: 2,9120

MALALTIES NEUROLòGIQUES, NEUROCIèNCIA I SALUT MENTAL

Malalties Cerobrovasculars

Principals línies de recerca

Reptes

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Principals línies de recerca

Reptes

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Institut de recerca de l’hospital de la santa creu i sant pau