Sant Pau - Institut de Recerca

Tissue procurement, clinical application, ethics and regulation.

Tissue decellularization approaches for clinical applications.
Cell-based therapy for ocular diseases.
3D bioimpression and biocompatible substrates.
Ex-vivo cell expansion for regenerative purposes.

Challenges

Optimization and improvement of technical procedures related to the donor and tissues. Advances in the elaboration of criteria, regulation and ethics for donor and tissues.
Technical excellence related to the processing cells, tissues and advanced therapies medical products (ATMP).
The development of new approaches and ATMPs for regenerative medicine.

Coordinació del grup

CASTELLS SALA CRISTINA BST
ccastells@bst.cat

Membres

Baptista Piteira, Ana Rita BST
Fariñas Barbera, Oscar BST
Martinez Conesa, Eva Maria BST
Rodriguez Martinez, Jose Ignacio BST
Ruiz Ponsell, Laia BST
Savio Lopez, Andres BST
Tabera Fernandez, Jaime BST

Publicacions 2021

Canut MI, Villa O, Kudsieh B, Mattlin H, Banchs I, Gonzalez JR, Armengol L, Casaroli RP. MLIP genotype as a predictor of pharmacological response in primary open-angle glaucoma and ocular hypertension. Scientific Reports. 2021; 11(1):1583. DOI:10.1038/s41598-020-80954-2. PMID:33452295. IF:4,996.
Duarri A, Rodríguez E, Martínez G, Biarnés M, García M, Ferraro LL, Kuebler B, Aran B, Izquierdo E, Aguilera E, Casaroli RP, Trias E, Fernandez E, Raya Á, Veiga A, Monés J. Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(19):10497. DOI:10.3390/ijms221910497. PMID:34638840. IF:6,208.
Figueras-Roca M, Parrado-Carrillo A, Nguyen V, Casaroli-Marano RP, Moll-Udina A, Gillies MC, Barthelmes D, Zarranz-Ventura J. Treat-and-extend versus fixed bimonthly treatment regimens for treatment-naive neovascular age-related macular degeneration: real world data from the Fight Retinal Blindness registry. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2021;259(6):1463-1470. DOI:10.1007/s00417-020-05016-9. PMID: 33219442. IF:3,535.
Garcia-Lopez J, Delgadillo J, Vilarrodona A, Querol S, Ovejo J, Coll R, Millan A, Madrigal A, Soria G, Vidal F, Vives J, Herrero MJ, Lopez I, Sauleda S, Contreras E, Grifols JR, Guasch R, Tahull E, Puig L, Masip A, Argelagués E, Muñiz-Diaz E. SARS-CoV-2/COVID-19 pandemic: first wave, impact, response and lessons learnt in a fully integrated Regional Blood and Tissue Bank. A narrative report. Blood Transfusion. 2021;19(2):158-167. DOI:10.2450/2021.0259-20. PMID: 33539280. IF:5,752.
Gelber PE, Ramirez E, Grau A, Gonzalez A, Llauger J, Farinas O. A new computed tomography scoring system to assess osteochondral allograft transplantation for the knee: inter-observer and intra-observer agreement. INTERNATIONAL ORTHOPAEDICS. 2021; 45(5). DOI:10.1007/s00264-020-04927-w. PMID:33416905. IF:3,479.
Nieto N, Lopez P, Farinas O, Bolivar S, Udina E, Navarro X, Casaroli RP, Vilarrodona A. Effective decellularization of human nerve matrix for regenerative medicine with a novel protocol. CELL AND TISSUE RESEARCH. 2021; 384(1). DOI:10.1007/s00441-020-03317-3. PMID:33471198. IF:4,051.
Nieto N, Martinez EM, Fuentes S, Arnalich F, Garcia I, De Miguel MP, Casaroli RP. Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021; 25(11). DOI:10.1111/jcmm.16501. PMID:33951289. IF:5,295.
Perez ML, Castells C, Lopez P, Nieto N, Aiti A, Farinas O, Casaroli RP, Porta O, Vilarrodona A. Fast protocol for the processing of split-thickness skin into decellularized human dermal matrix. TISSUE & CELL. 2021; 72:101572. DOI:10.1016/j.tice.2021.101572. PMID:34119882. IF:2,586.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Piteira AR, Bofill AM, Farinas O, Tabera J, Vilarrodona A. Lessons Learned From SARS-CoV-2 Pandemic in Donation and Tissue Banking Activities: Key Takeaways. TRANSPLANTATION. 2021; 105(7). DOI:10.1097/TP.0000000000003716. PMID:34019361. IF:5,385.
Sabater N, Figueras M, Ferran M, Agusti E, Martinez EM, Perez ML, Vilarrodona A, Casaroli RP. Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice. INTERNATIONAL OPHTHALMOLOGY. 2021; 41(9). DOI:10.1007/s10792-021-01856-4. PMID:33864578. IF:2,029.
Sabater N, Figueras M, Padro L, Tort J, Casaroli RP. Corneal transplantation activity in Catalonia, Spain, from 2011 to 2018: Evolution of indications and surgical techniques. PLoS One. 2021; 16(4):e0249946. DOI:10.1371/journal.pone.0249946. PMID:33831081. IF:3,752.
Sabater N, Otero N, Dotti M, Rios J, Gris O, Guell JL, Vilarrodona A, Casaroli RP. Eye bank and theatre factors for positive microbiological culture of corneoscleral rim and cornea storage medium in the real-world. EYE. 2021; 35(11). DOI:10.1038/s41433-020-01342-8. PMID:33469128. IF:4,456.
Samarkanova D, Cox S, Hernandez D, Rodriguez L, Perez ML, Madrigal A, Vilarrodona A, Querol S, Casaroli RP. Cord blood and amniotic membrane extract eye drop preparations display immune-suppressive and regenerative properties. Scientific Reports. 2021; 11(1):13754. DOI:10.1038/s41598-021-93150-7. PMID:34215804. IF:4,996.
Samarkanova D, Martin S, Bisbe L, Puig J, Calatayud M, Rodriguez L, Azqueta C, Coll R, Casaroli R, Madrigal A, Rebulla P, Querol S, Barcelona Cbed Study GRP. Clinical evaluation of allogeneic eye drops from cord blood platelet lysate. Blood Transfusion. 2021; 19(4). DOI:10.2450/2020.0130-20. PMID:33085593. IF:5,752.

Publicacions 2020

Canamary Jr AM, Monteiro IR, Machado MKM, Regatieri CVS, Pereira Silva LM, Casaroli-Marano RP, Muccioli C. Quality-of-Life and psychosocial aspects in patients with ocular toxoplasmosis: A clinical study in a tertiary care hospital in Brazil. OCUL IMMUNOL INFLAMM. 2020;28(4):679-687. doi: 10.1080/09273948.2019.1612453. IF: 3,0700

Casaroli-Marano RP, Bernal-Morales C, Chamorro-López L, Dotti-Boada M, Figueroa-Vercellino JP, Alforja S. Aflibercept in real-world unselected naïve-patients with neovascular age-related macular degeneration. J OPHTHALMOL. 2020; doi: 10.1155/2020/8848336. IF: 1,9090

Castella M, Caballero-Baños M, Ortiz-Maldonado V, González-Navarro EA, Suñé G, Antoñana-Vidósola A, Boronat A, Marzal B, Millán L, Martín-Antonio B, Cid J, Lozano M, García E, Tabera J, Trias E, Perpiña U, Canals JM, Baumann T, Benítez-Ribas D, Campo E, Yagüe J, Urbano-Ispizua Á, Rives S, Delgado J, Juan M. Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial. FRONT IMMUNOL. 2020 Mar 20;11:482. eCollection 2020. PMID: 32528460. 11, pp.482. doi: 10.3389/fimmu.2020.00482. IF: 7,5610

Erivan R., Lopez-Chicon P., Farinas O., Perez Prieto D., Grau S., Boisgard S., Monllau J.C., Vilarrodona A. (2020) Which type of bone releases the most vancomycin? Comparison of spongious bone, cortical powder and cortico-spongious bone. CELL TISSUE BANK, 21 (1), 131-137. IF: 1,5220

Fernandez Zamora Y., Finamor L.P., Silva L.M.P., Rodrigues D.S., Casaroli-Marano R.P., Muccioli C. (2020) Current Practices in Ocular Tuberculosis: A Survey of Brazilian Specialists. OCUL IMMUNOL INFLAMM, 28 (2), 256-261. IF: 3,0700

Figueras-Roca M, Parrado-Carrillo A, Nguyen V, Casaroli-Marano RP, Moll-Udina A, Gillies MC, Barthelmes D, Zarranz-Ventura J. Treat-and-extend versus fixed bimonthly treatment regimens for treatment-naive neovascular age-related macular degeneration: real world data from the Fight Retinal Blindness registry. GRAEFES ARCH CLIN EXP OPHTHALMOL. 2020. doi: 10.1007/s00417-020-05016-9. IF: 3,1170

Garcia-Medina JJ, Rubio-Velazquez E, Foulquie-Moreno E, Casaroli-Marano RP, Pinazo Duran MD, Zanon-Moreno V, del-Rio-Vellosillo M. Update on the effects of antioxidants on Diabetic Retinopathy: in vitro experiments, animal studies and clinical trials. ANTIOXIDANTS 2020; 9(6):561; doi:10.3390/antiox9060561. IF: 6,3120

Iglesias M., Yebra F., Kudsieh B., Laiseca A., Santos C., Nadal J., Barraquer R., Casaroli-Marano R.P. (2020) New applanation tonometer for myopic patients after laser refractive surgery. SCI REP-UK, 10 (1), -. IF: 4,3790

Méndez-Lara KA, Letelier N, Farré N, Diarte-Añazco EMG, Nieto-Nicolau N, Rodríguez-Millán E, Santos D, Pallarès V, Escolà-Gil JC, Vázquez Del Olmo T, Lerma E, Camacho M, Casaroli-Marano RP, Valledor AF, Blanco-Vaca F, Julve J. Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice. ANTIOXIDANTS (BASEL). 2020;9:1162. doi: 10.3390/antiox9111162. IF: 6,3120

Moll-Udina A, Alforja-Castiella S, Figueroa-Vercellino JP, Alé-Chilet A, Casaroli-Marano RP. Simultaneous Retinal pigment epithelium tear and lamellar macular hole evolving to a full-thickness macular hole after intravitreal therapy. J FR OPHTALMOL. 2020; S0181-5512(20)30243-6. doi: 10.1016/j.jfo.2019.11.010. IF: 0,8180

Nieto-Nicolau N, De La Torre RM, Fariñas O, Savio A, Vilarrodona A, Casaroli-Marano RP. Extrinsic modulation of integrin and progenitor cell behavior in mesenchymal stem cells. STEM CELL RES. 2020 Jun 30;47:101899. Epub ahead of print. PMID: 32659733. doi: 10.1016/j.scr.2020.101899. IF: 6,8320

Nieto-Nicolau N, de la Torre RM, Fariñas O, Savio A, Vilarrodona A, Casaroli-Marano RP. Extrinsic modulation of integrin α6 and progenitor cell behavior in mesenchymal stem cells. STEM CELL RES. 2020; 47:101899. doi: 10.1016/j.scr.2020.101899. IF: 6,8320

Nieto-Nicolau N., Martin-Antonio B., Muller-Sanchez C., Casaroli-Marano R.P. (2020) In vitro potential of human mesenchymal stem cells for corneal epithelial regeneration. REGEN MED, 15 (3), 1409-1426. IF: 3,8060

Pereira B.S., van Dijk C.N., Andrade R., Casaroli-Marano R.P., Espregueira-Mendes J., Oliva X.M. (2020) The calcaneofibular ligament has distinct anatomic morphological variants: an anatomical cadaveric study. KNEE SURG SPORT TR A, 28 (1), 40-47. IF: 4,3420

Prat-Vidal C, Rodríguez-Gómez L, Aylagas M, Nieto-Nicolau N, Gastelurrutia P, Agustí E, Gálvez-Montón C, Jorba I, Teis A, Monguió-Tortajada M, Roura S, Vives J, Torrents-Zapata S, Coca MI, Reales L, Cámara-Rosell ML, Cediel G, Coll R, Farré R, Navajas D, Vilarrodona A, García-López J, Muñoz-Guijosa C, Querol S, Bayes-Genis A. First-in-human PeriCord cardiac bioimplant: Scalability and GMP manufacturing of an allogeneic engineered tissue graft. EBIOMEDICINE. 2020 Apr;54:102729. Epub 2020 Apr 15. doi: 10.1016/j.ebiom.2020.102729. IF: 8,1430

Sabater-Cruz N, Dotti-Boada M, Rios J, Carrion MT, Chamorro L, Sánchez-Dalmau BF, Casaroli-Marano RP. Postoperative treatment compliance rate and complications with two different protocols after pterygium excision and conjunctival autografting. Eur J Ophthalmol. 2020; doi: 10.1177/1120672120917335. IF: 2,5970

Sabater-Cruz N, Figueras-Roca M, González Ventosa A, Padró-Pitarch L, Tort J, Casaroli-Marano RP. Current clinical application of sclera and amniotic membrane for ocular tissue bio-replacement. CELL TISS BANK 2020;21(4):597-603. doi: 10.1007/s10561-020-09848-x. IF: 1,5220

Samarkanova D, Cox S, Hernandez D, Rodriguez L, Casaroli-Marano RP, Madrigal A, Querol S. Cord blood Platelet Rich Plasma derivatives for clinical applications in non-transfusion medicine. FRONT IMMUNOL. 2020;11:942. doi: 10.3389/fimmu.2020.00942. 11:942. IF: 7,5610

Samarkanova D, Martin S, Bisbe L, Puig J, Calatayud-Pinuaga M, Rodriguez L, Azqueta C, Coll R, Casaroli-Marano R, Madrigal A, Rebulla P, Querol S; Barcelona CBED Study Group. Clinical evaluation of allogeneic eye drops from cord blood platelet lysate. BLOOD TRANSFUS. 2020 doi: 10.2450/2020.0130-20. IF: 3,4430

Trias E., Gallon P., Ferrari S., Piteira A.R., Tabera J., Casaroli-Marano R.P., Parekh M., Ruzza A., Franch A., Ponzin D. (2020) Banking of corneal stromal lenticules: a risk-analysis assessment with the EuroGTP II interactive tool. CELL TISSUE BANK, 21 (2), 189-204. IF: 1,5220

Trias E, Lomas R, Tabeira J, Piteira AR, Tilleman K, Casaroli-Marano RP, Chandrasekar A. On behalf of EuroGTP II Study Group. EuroGTPII: A Tool to assess risk, safety and efficacy of substances of human origin. INT J QUAL HEALTH CARE. 2020;32(1):80-84. doi: 10.1093/intqhc/mzz048. IF: 2,0380

Trias E, Nijs M, Rugescu IA, Lombardo F, Nikolov G, Provoost V, Tolpe A, Vermeulen N, Veleva Z, Piteira R, Casaroli-Marano RP, Tilleman K, EuroGTP II Study Group. Evaluating risk, safety and efficacy of novel reproductive techniques and therapies through the EuroGTP II risk assessment tool. HUMAN REPRODUCTION. 2020, 35(8). Doi: 10.1093/humrep/deaa146. IF: 6,9180

Vilaplana F, Nadal J, Temprano J, Julio G, Olivera M, Casaroli-Marano RP, Barraquer RI. Vitrectomy for endophthalmitis in eyes with osteokeratoprothesis. RETINA. 2020;40(5):903-907. doi: 10.1097/IAE.0000000000002495. IF: 4,2560

Yamamoto L, Zarbin MA, Casaroli-Marano RP. New frontiers and clinical implications in the pathophysiology of age-related macular degeneration. MED CLIN (BARC). 2020;154(12):496-504. doi: 10.1016/j.medcli.2020.01.023. IF: 1,7250

presentació

Tissue procurement, clinical application, ethics and regulation.

Tissue decellularization approaches for clinical applications.
Cell-based therapy for ocular diseases.
3D bioimpression and biocompatible substrates.
Ex-vivo cell expansion for regenerative purposes.

Challenges

Optimization and improvement of technical procedures related to the donor and tissues. Advances in the elaboration of criteria, regulation and ethics for donor and tissues.
Technical excellence related to the processing cells, tissues and advanced therapies medical products (ATMP).
The development of new approaches and ATMPs for regenerative medicine.

equip

Coordinació del grup

CASTELLS SALA CRISTINA BST
ccastells@bst.cat

Membres

producció científica

Publicacions 2021

Canut MI, Villa O, Kudsieh B, Mattlin H, Banchs I, Gonzalez JR, Armengol L, Casaroli RP. MLIP genotype as a predictor of pharmacological response in primary open-angle glaucoma and ocular hypertension. Scientific Reports. 2021; 11(1):1583. DOI:10.1038/s41598-020-80954-2. PMID:33452295. IF:4,996.
Duarri A, Rodríguez E, Martínez G, Biarnés M, García M, Ferraro LL, Kuebler B, Aran B, Izquierdo E, Aguilera E, Casaroli RP, Trias E, Fernandez E, Raya Á, Veiga A, Monés J. Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(19):10497. DOI:10.3390/ijms221910497. PMID:34638840. IF:6,208.
Figueras-Roca M, Parrado-Carrillo A, Nguyen V, Casaroli-Marano RP, Moll-Udina A, Gillies MC, Barthelmes D, Zarranz-Ventura J. Treat-and-extend versus fixed bimonthly treatment regimens for treatment-naive neovascular age-related macular degeneration: real world data from the Fight Retinal Blindness registry. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2021;259(6):1463-1470. DOI:10.1007/s00417-020-05016-9. PMID: 33219442. IF:3,535.
Garcia-Lopez J, Delgadillo J, Vilarrodona A, Querol S, Ovejo J, Coll R, Millan A, Madrigal A, Soria G, Vidal F, Vives J, Herrero MJ, Lopez I, Sauleda S, Contreras E, Grifols JR, Guasch R, Tahull E, Puig L, Masip A, Argelagués E, Muñiz-Diaz E. SARS-CoV-2/COVID-19 pandemic: first wave, impact, response and lessons learnt in a fully integrated Regional Blood and Tissue Bank. A narrative report. Blood Transfusion. 2021;19(2):158-167. DOI:10.2450/2021.0259-20. PMID: 33539280. IF:5,752.
Gelber PE, Ramirez E, Grau A, Gonzalez A, Llauger J, Farinas O. A new computed tomography scoring system to assess osteochondral allograft transplantation for the knee: inter-observer and intra-observer agreement. INTERNATIONAL ORTHOPAEDICS. 2021; 45(5). DOI:10.1007/s00264-020-04927-w. PMID:33416905. IF:3,479.
Nieto N, Lopez P, Farinas O, Bolivar S, Udina E, Navarro X, Casaroli RP, Vilarrodona A. Effective decellularization of human nerve matrix for regenerative medicine with a novel protocol. CELL AND TISSUE RESEARCH. 2021; 384(1). DOI:10.1007/s00441-020-03317-3. PMID:33471198. IF:4,051.
Nieto N, Martinez EM, Fuentes S, Arnalich F, Garcia I, De Miguel MP, Casaroli RP. Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021; 25(11). DOI:10.1111/jcmm.16501. PMID:33951289. IF:5,295.
Perez ML, Castells C, Lopez P, Nieto N, Aiti A, Farinas O, Casaroli RP, Porta O, Vilarrodona A. Fast protocol for the processing of split-thickness skin into decellularized human dermal matrix. TISSUE & CELL. 2021; 72:101572. DOI:10.1016/j.tice.2021.101572. PMID:34119882. IF:2,586.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Piteira AR, Bofill AM, Farinas O, Tabera J, Vilarrodona A. Lessons Learned From SARS-CoV-2 Pandemic in Donation and Tissue Banking Activities: Key Takeaways. TRANSPLANTATION. 2021; 105(7). DOI:10.1097/TP.0000000000003716. PMID:34019361. IF:5,385.
Sabater N, Figueras M, Ferran M, Agusti E, Martinez EM, Perez ML, Vilarrodona A, Casaroli RP. Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice. INTERNATIONAL OPHTHALMOLOGY. 2021; 41(9). DOI:10.1007/s10792-021-01856-4. PMID:33864578. IF:2,029.
Sabater N, Figueras M, Padro L, Tort J, Casaroli RP. Corneal transplantation activity in Catalonia, Spain, from 2011 to 2018: Evolution of indications and surgical techniques. PLoS One. 2021; 16(4):e0249946. DOI:10.1371/journal.pone.0249946. PMID:33831081. IF:3,752.
Sabater N, Otero N, Dotti M, Rios J, Gris O, Guell JL, Vilarrodona A, Casaroli RP. Eye bank and theatre factors for positive microbiological culture of corneoscleral rim and cornea storage medium in the real-world. EYE. 2021; 35(11). DOI:10.1038/s41433-020-01342-8. PMID:33469128. IF:4,456.
Samarkanova D, Cox S, Hernandez D, Rodriguez L, Perez ML, Madrigal A, Vilarrodona A, Querol S, Casaroli RP. Cord blood and amniotic membrane extract eye drop preparations display immune-suppressive and regenerative properties. Scientific Reports. 2021; 11(1):13754. DOI:10.1038/s41598-021-93150-7. PMID:34215804. IF:4,996.
Samarkanova D, Martin S, Bisbe L, Puig J, Calatayud M, Rodriguez L, Azqueta C, Coll R, Casaroli R, Madrigal A, Rebulla P, Querol S, Barcelona Cbed Study GRP. Clinical evaluation of allogeneic eye drops from cord blood platelet lysate. Blood Transfusion. 2021; 19(4). DOI:10.2450/2020.0130-20. PMID:33085593. IF:5,752.

MEDICINA TRANSLACIONAL

Medicina Regenerativa i Bioenginyeria de Teixits

Tissue procurement, clinical application, ethics and regulation.

Challenges

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Tissue procurement, clinical application, ethics and regulation.

Challenges

Coordinació del grup

Membres

Publicacions 2021

Publicacions 2020

Institut de recerca de l’hospital de la santa creu i sant pau